Senior Director, Toxicology

Disc Medicine•Massachusetts - Hybrid, MA

15h•$261,000 - $319,000•Hybrid

About The Position

Disc Medicine is seeking an experienced, strategic Senior Director, Toxicology to join our team. Reporting directly to the Vice President, Head of Toxicology, the successful candidate will play a pivotal role in leading nonclinical safety assessments and driving toxicology strategy across the Disc portfolio. The successful candidate will provide critical safety expertise from early-stage discovery and IND-enabling studies through to global market authorizations. The ideal candidate will also blend deep technical knowledge in nonclinical safety and pharmacokinetics with strong communication skills to cross-functionally guide programs toward clinical success.

Requirements

Ph.D. in toxicology with 10-14 years of experience overseeing toxicology programs and conducting GLP toxicology studies within the pharmaceutical industry
Strong understanding of global toxicology guidelines, such as ICH, FDA, and EMA
Planning and execution of IND-enabling studies to support first-in-human studies
Planning and execution of late-stage nonclinical toxicity studies
Strong expertise in writing and presenting nonclinical safety data within Common Technical Documents for submission to regulatory authorities (e.g., IND, NDA, MAA)
Possesses excellent interpersonal, organizational, and communication skills
Great collaboration and teamwork skills. Experience in cross-functional interactions in matrix teams
Track record of scientific excellence in toxicology or related scientific areas, evidenced by publications in scientific journals and/or presentations at scientific conferences

Nice To Haves

Experience with both large and small molecule drug development
Experience in hematology and rare disease drug development
A.B.T certification

Responsibilities

Design, execute, and interpret nonclinical safety studies across all phases of drug development, including GLP toxicology, reproductive toxicology, carcinogenicity, and safety pharmacology work.
Sound background and understanding of pharmacokinetic data to establish appropriate scientific justifications for toxicology study dose justifications and selection of safe and effective clinical doses.
Oversight of budgets, timelines, and study monitoring and willing to visit GLP testing sites to review facilities and capabilities.
Partner closely with clinical development, technical operations, DMPK/clinical pharmacology, discovery, and program teams to provide concise presentations on data interpretation and strategy.
Knowledge of nonclinical regulatory frameworks and ability to draft relevant toxicology sections of regulatory documents (e.g., IND, IB, IMPD, BLA, NDA, etc.).