Senior Director, Legal and Compliance Operations

Madrigal Pharmaceuticals•PA - Pennsylvania – Remote, PA

7d•$254,000 - $311,000

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Senior Director, Legal and Compliance Operations, is a key leader responsible for supporting the execution and continuous improvement of Madrigal’s Compliance Program. This role focuses on project management, policy governance and operational excellence across the Legal and Compliance function. The Senior Director partners closely with the Global Compliance Officer, Chief Legal Officer, and cross-functional stakeholders, including Compliance, Legal, Commercial, Medical Affairs, Market Access, and IT—to ensure legal and compliance initiatives are effectively implemented and aligned with business objectives. This role plays a critical part in strengthening a culture of integrity, transparency, and ethical decision-making across the organization. The ideal candidate brings deep expertise in healthcare compliance and legal operations, along with a practical, solutions-oriented approach to implementing scalable processes, enhancing training effectiveness, and advancing compliance program maturity. This role offers the opportunity to play a meaningful part in advancing a high-impact compliance program while partnering across the organization to support business success through strong, practical compliance practices.

Requirements

Bachelor’s degree required; advanced degree (JD, MBA, or Master’s) strongly preferred.
12–15+ years of progressive experience in pharmaceutical or biotech compliance, legal, or related functions.
Demonstrated success in implementing policy governance frameworks and compliance training programs.
Strong leadership capability, organizational awareness, sound judgment, and business acumen, with the ability to make informed decisions in collaboration with stakeholders.
Excellent interpersonal, written, and presentation skills.
Proven ability to operate effectively in a fast-paced, high-growth environment while maintaining a focus on quality, ethics, and collaboration.
Knowledge of laws, regulations, and industry guidance relevant to the pharmaceutical industry.
Strong collaboration skills and ability to work effectively across cross-functional teams.
Strong problem-solving and risk assessment capabilities.
Ability to prioritize and manage multiple complex and confidential initiatives simultaneously.

Responsibilities

Partner with Compliance and Legal team members to maintain and enhance infrastructure that supports a culture of compliance and shared accountability across the organization.
Project management tied to legal and compliance operational excellence with sub-functions - creating metrics /key performance indicators/dashboards, etc.
Collaborate cross-functionally to identify policy and guidance needs; develop and refine policies, procedures, and supporting documentation to ensure clarity and usability.
Lead the design, implementation, and continuous improvement of risk-based compliance training programs tailored to functional audiences.
Support the annual compliance risk assessment process, including data gathering, analysis, and identification of areas for program enhancement.
Provide practical compliance guidance to business stakeholders and support the integration of compliance controls into existing business processes.
Drive continuous improvement initiatives, including documentation, tracking, and reporting of compliance activities and program effectiveness.
Maintain current knowledge of applicable laws, regulations, and industry guidance, including federal and state pricing regulations, privacy laws, OIG and DOJ guidance, the PhRMA Code, and state marketing compliance requirements.
Lead and execute high-impact legal and compliance projects and cross-functional initiatives as assigned by the Chief Legal Officer or Global Compliance Officer.