Senior Director, In Vivo Pharmacology

Rezo Therapeutics•San Francisco, CA

12d•$195,000 - $290,000•Onsite

About The Position

Rezo Therapeutics is a biopharma company focused on increasing drug development success rates through a disease-agnostic, integrated network biology platform. They combine genetics, proteomics, structural biology, and AI to gain biological insights and develop novel therapeutics. Located in San Francisco's Mission Bay, Rezo aims to foster a collaborative, respectful, and diverse workplace. Rezo is seeking an experienced Director/Senior Director of In Vivo Pharmacology to lead the strategy, design, execution, and interpretation of in vivo pharmacology studies for their oncology portfolio. The ideal candidate will have deep expertise in oncology models, PK/PD-driven study design, translational pharmacology, and cross-functional drug discovery. This role involves working closely with biology, medicinal chemistry, DMPK, and external CRO partners to generate robust data. This is an opportunity to build and shape the in vivo pharmacology function at a growing oncology biotech, with a direct impact on program strategy and portfolio progression.

Requirements

PhD in pharmacology, cancer biology, molecular biology, physiology, translational medicine, or a related discipline, with typically 10+ years of relevant industry experience in oncology drug discovery or translational pharmacology.
Deep expertise in in vivo pharmacology for small-molecule oncology drug discovery.
Strong track record designing and interpreting efficacy, PK/PD, dose-response, dose-scheduling, and mechanism-of-action studies in oncology models.
Hands-on experience with rodent oncology models and a strong understanding of the strengths, limitations, and translational relevance of CDX, PDX, and syngeneic models.
Demonstrated ability to integrate in vivo pharmacology with medicinal chemistry, DMPK, and biomarker strategy.
Experience advancing programs from discovery through development candidate nomination.
Strong CRO management experience, including protocol design, study oversight, data QC, troubleshooting, and vendor accountability.
Ability to operate at both strategic and detailed execution levels in a small-company setting.

Responsibilities

Lead the in vivo pharmacology strategy for Rezo’s small-molecule oncology programs, including study design, model selection, dose/schedule optimization, PK/PD integration, efficacy assessment, and translational interpretation.
Design and oversee in vivo studies in CDX, PDX, syngeneic, as appropriate for each program and mechanism.
Develop pharmacology plans that support development candidate nomination, IND-readiness, and early clinical translational strategy.
Integrate tumor efficacy, exposure, pharmacodynamic biomarkers, tolerability, and mechanism-of-action data to guide compound prioritization and program decisions.
Mentor and potentially manage scientists as the organization grows.