Senior Director, HEOR – Acoramidis (Global Lead)

BridgeBio Pharma•San Francisco, CA

5h•Hybrid

About The Position

BridgeBio is seeking a highly strategic and execution-oriented HEOR leader to define and drive the global evidence strategy for acoramidis in ATTR-CM. This individual will play a pivotal role in enabling successful global launch, optimizing payer access, and sustaining long-term product differentiation in an increasingly competitive and evolving landscape. As the global HEOR lead, this role will shape the evidence generation agenda across the product lifecycle—spanning clinical development, launch, and post-marketing—leveraging real-world evidence (RWE), comparative effectiveness research, and patient-centered outcomes. The leader will serve as a key partner to Market Access, Medical Affairs, Clinical Development, and Commercial teams to ensure evidence translates into impactful value narratives for payers and HTA bodies worldwide. Acoramidis represents a transformative opportunity in ATTR-CM. This role is central to articulating and proving its value to patients, providers, and payers globally. By shaping the evidence strategy and driving impactful insights, this leader will directly influence access, adoption, and long-term success in a competitive and rapidly evolving therapeutic area.

Requirements

Advanced degree (PhD, PharmD, MPH, MD, or equivalent) in health economics, outcomes research, epidemiology, or related field
10+ years of progressive HEOR experience within biopharma or consulting, including leadership of global programs
Demonstrated experience supporting product launches and payer strategy development in specialty or rare diseases preferred
Strong understanding of global HTA frameworks (e.g., NICE, ICER, CADTH, G-BA) and payer evidence requirements
Proven track record in RWE, economic modeling, and PRO strategy development
Strategic, enterprise-level thinker with strong business acumen
Ability to translate complex evidence into clear, compelling value narratives for diverse stakeholders
Influential cross-functional leader with a collaborative and proactive mindset
Strong project leadership and ability to manage multiple priorities in a fast-paced environment
Executive presence with excellent communication and stakeholder engagement skills

Responsibilities

Define and lead the end-to-end global HEOR strategy for acoramidis across launch and lifecycle, ensuring alignment with clinical, regulatory, and commercial objectives and driving evidence-based decision-making
Design and oversee innovative real-world evidence (RWE), economic models, and data partnerships (e.g., claims, EHR, observational survey datasets) to support value demonstration and long-term evidence generation
Develop robust, payer-relevant evidence packages and lead HEOR contributions to global HTA submissions, pricing, reimbursement, and access strategies
Lead the HEOR publication strategy, including congress planning and peer-reviewed publications with Pubs teams, to establish a compelling and credible evidence narrative
Drive the development and integration of PROs and other patient-centered endpoints to demonstrate meaningful clinical benefit and differentiation
Proactively assess and anticipate competitive dynamics (including generics, pipeline entrants, and alternative therapies) to inform evidence strategy and positioning
Partner closely with Market Access, Medical Affairs, Clinical, Regulatory, and Commercial teams to ensure cohesive and actionable evidence strategies
Ensure HEOR activities are conducted with scientific rigor and appropriate governance, maintaining independence of evidence generation while enabling compliant, impactful use
Oversee external vendors, research partners, and academic collaborations to deliver high-quality, timely evidence outputs

Benefits

Market-leading compensation
401(k) with employer match
Employee Stock Purchase Program (ESPP)
Pre-tax commuter benefits (transit and parking)
Referral bonus for hired candidates
Subsidized lunch and parking on in-office days
100% employer-paid medical, dental, and vision premiums for you and your dependents
Health Savings Account (HSA) with annual employer contributions, plus Flexible Spending Accounts (FSA)
Fertility & family-forming benefits
Expanded mental health support (therapy and coaching resources)
Hybrid work model with flexibility
Flexible, “take-what-you-need” paid time off and company-paid holidays
Comprehensive paid medical and parental leave to care for yourself and your family
Career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching