Senior Director, Head of Marketing

BridgeBio Pharma • San Francisco, CA

3d • Hybrid

About The Position

This role is for a seasoned rare disease commercialization leader who thrives at the intersection of science, strategy, and execution. The individual will have led or been a critical architect of at least one rare disease launch and understands the nuances of a small-patient, high-science category. The Senior Director, Head of Marketing will serve as the commercial brand authority for Calci (encaleret), BridgeBio's oral CaSR negative allosteric modulator in NDA review for Autosomal Dominant Hypocalcemia Type 1 (ADH1). This is a first-in-class asset targeting a chronically underserved rare endocrine population, and this role represents a defining commercial leadership opportunity. The position requires owning the full marketing function for Calci, including HCP marketing, patient marketing, and KOL engagement under a single integrated brand strategy. The role reports directly to the SVP, Sales & Marketing — Endocrinology and requires weekly on-site presence in both San Francisco and Palo Alto offices. This is a role for someone who can write the playbook, not follow one.

Requirements

• 12+ years of commercial biotech or pharmaceutical experience, with at least 7 years in pharmaceutical/biotech marketing
• Prior people management experience required; experience building or scaling a marketing team in a launch setting strongly preferred
• Rare disease launch experience required — endocrinology or nephrology experience is a significant differentiator
• Demonstrated success owning brand strategy through launch, including brand planning, promotional development, and commercial execution
• Proven track record leading KOL engagement programs and commercial advisory board design
• Experience developing and managing both HCP and patient marketing strategies simultaneously
• Comfort operating in a pre-launch, high-ambiguity environment — able to set direction and drive execution before full commercial infrastructure is in place
• Strong working knowledge of FDA promotional guidelines, fair balance, and rare disease compliance requirements
• Exceptional oral, written, and executive presentation skills — including comfort with BOD-level deliverables
• Ability to travel (~25%) for key congresses, advisory boards, and field engagement
• Bachelor's degree required

Nice To Haves

• MBA or advanced science degree preferred

Responsibilities

• Own the Calci brand strategy end-to-end — positioning, messaging architecture, segmentation, and go-to-market sequencing — ensuring full alignment from pre-NDA approval through Year 1+ commercialization
• Lead all brand planning milestones, including annual brand plan, launch readiness assessments, and BOD-level commercial reporting
• Serve as the senior commercial voice on the Calci Product Team, embedding market realities into cross-functional planning across Medical Affairs, Regulatory, Market Access, and Patient Advocacy
• Build and maintain a dynamic competitive intelligence function, monitoring the ADH1 and broader hypoparathyroidism landscape and translating findings into strategic decisions
• Partner with Value & Access to shape the payer value proposition and ensure access strategies are integrated into brand planning from day one
• Directly lead and develop a team of 4, including: Director, HCP Marketing; Director, Patient Marketing; and two KOL Engagement Leads — setting individual performance goals, coaching toward professional growth, and building a cohesive, high-performing marketing organization
• Foster a culture of intellectual rigor, creative ambition, and patient-first accountability across the marketing team
• Act as the connector between team workstreams, ensuring HCP, patient, and KOL strategies are mutually reinforcing and aligned under one brand narrative
• Develop the next generation of commercial talent within the team through active mentorship, stretch assignments, and transparent performance management
• Oversee the development of a field-ready HCP promotional platform — including clinical messaging, EAM enablement tools, and channel strategy — built on deep insight into endocrinologist and nephrologist decision-making
• Ensure EAM (Endocrine Account Manager) engagement materials reflect the Calci scientific story with precision, clarity, and promotional compliance
• Lead commercial advisory boards and insight-generation programs to continuously refine HCP strategy and ensure message resonance
• Partner with Market Insights to develop HCP segmentation and targeting frameworks, including tiered engagement models for high-value prescribers
• Guide the patient marketing director in developing a robust DTC and patient-facing strategy, with a focus on diagnosis acceleration, disease education, and treatment adherence for ADH1 patients
• Oversee the commercial patient support ecosystem in partnership with specialty pharmacy and patient services, ensuring a seamless patient journey from identification through persistency
• Champion familial cascade testing as a patient identification lever, ensuring that commercial programs support structured proband communication and relative testing uptake
• Provide strategic direction to two KOL Engagement Leads, ensuring a coordinated, insight-driven KOL plan that spans identification, profiling, advisory board engagement, and speaker bureau development
• Oversee commercial KOL congress strategy and ensure BridgeBio's Calci commercial presence at key endocrine and rare disease meetings is impactful and insight-generating
• Guide the development and governance of the commercial speaker bureau program in alignment with compliance and legal requirements
• Work with Market Insights to build and pressure-test launch forecasting models and establish measurable KPIs across all marketing programs
• Develop and present commercial updates to senior leadership and the Board of Directors, synthesizing brand performance, market dynamics, and strategic pivots
• Establish a metrics-driven culture within the marketing team, driving accountability against leading and lagging brand indicators

Benefits

• Market-leading compensation
• Annual performance bonus
• Company equity
• 401(k) with employer match
• Employee Stock Purchase Program (ESPP)
• Pre-tax commuter benefits (transit and parking)
• Referral bonus for hired candidates
• Subsidized lunch and parking on in-office days
• 100% employer-paid medical, dental, and vision premiums for you and your dependents
• Health Savings Account (HSA) with annual employer contributions
• Flexible Spending Accounts (FSA)
• Fertility & family-forming benefits
• Expanded mental health support (therapy and coaching resources)
• Hybrid work model with flexibility
• Flexible, “take-what-you-need” paid time off and company-paid holidays
• Comprehensive paid medical and parental leave to care for yourself and your family
• Career pathing through regular feedback, continuous education and professional development programs via LinkedIn Learning, LifeLabs, & BetterUp Coaching

What This Job Offers

• Job Type: Full-time
• Career Level: Senior