Senior Director, Engineering and Materials Science

Vertex Inc.•Boston, MA

1d•Onsite

About The Position

Vertex is seeking a talented individual to join the Engineering and Materials Science department in Boston, MA. The successful candidate will be a productive, results-oriented leader who is able to lead a diverse team of engineers and scientists and contribute to the successful development and scale-up of drug substance and drug product candidates. Excellent leadership, interpersonal, and organization skills as well as a high level of technical aptitude and creativity are required for success in this position.

Requirements

Experience leading a team of engineers/scientists in pharmaceutical process development
Advanced knowledge of standard unit operations encountered in small molecule and/or Oligonucleotide drug substance process development inclusive of particle engineering, reaction kinetics, thermodynamics, and transport fundamentals
Have demonstrated experience with modeling complex, physicochemical systems, data analysis, statistical design of experiments, QbD concepts, and fluency with common physical property and process modeling tools
Demonstrated process scale up and regulatory dossier authoring.
Experience with process development and problem solving in a matrix environment
Strong communication skills and the ability to influence both stakeholders and team members

Responsibilities

Be responsible for leading and developing a cross-functional team of engineers and scientists in defining, developing, and demonstrating viable, multi-step syntheses for the robust manufacture of small-molecule or oligonucleotide active pharmaceutical ingredients, spanning all phases of clinical development through to commercialization and launch
Lead drug substance process development efforts and apply sound scientific judgement to drive multiple assets in a fast-paced environment via laboratory development, modeling, drug supply preparation, and technology transfer to third party manufacturing facilities
Collaborate with materials discovery, process chemistry, analytical development, and formulation groups to improve the overall discovery/development process for definition and optimization of drug substance properties and performance across the clinical development spectrum
Drive the adoption of process modeling within the department.
Potentially lead projects, representing all aspects of pharmaceutical sciences
Be at the forefront of industry best practices and promote innovation.
Be vested in developing team members and technically mentoring junior-level scientists
Influence departmental strategic direction
Use excellent communication and interpersonal skills to influence stakeholders and interact, lead, and collaborate within an interdisciplinary team comprised of chemical engineers, organic, physical, and analytical chemists, materials and solid-state scientists, and formulation development personnel