Senior Director, Commercial Forecasting & Artificial Intelligence

Immatics • Houston, TX

12d • Remote

About The Position

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME , a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Role Overview We are seeking a Senior Director, Commercial Forecasting & AI combined role. Approximately half of the position is owning demand, revenue and patient-flow forecasting across Immatics’ portfolio — from early pipeline opportunity assessment through launch readiness and in-line performance. The other half is serving as the Commercial organization’s in-house AI expert: identifying, building and scaling AI and generative-AI capabilities that make a small commercial team perform like a much larger one. The successful candidate is a recognized forecasting expert in oncology or cell and gene therapy who has already put AI to practical, compliant use in a life sciences commercial setting.

Requirements

• Bachelor’s or equivalent years of experience
• 15+ years in Life sciences consultancy, biotech, pharma or related
• 7 Years of Forecasting, Commercial Analytics or market insights
• Demonstrated expertise building patient-based and epidemiology-driven forecast models from the ground up for both pre-launch and in-line assets.
• Deep working knowledge of pharma/biotech data sources and their strengths and limitations — e.g. IQVIA, Symphony Health, Komodo, Definitive Healthcare, specialty distributor and 867/852 data, SEER and other epidemiology sources, clinical registries and syndicated market research.
• Demonstrated, hands-on experience applying AI and large language models to real commercial problems in a regulated life sciences environment — including practical fluency with LLM platforms, prompt engineering, retrieval-augmented generation and agentic workflows, and a clear-eyed view of where AI does and does not work.
• Working understanding of the compliance and privacy constraints on AI in life sciences (PHI/HIPAA, GDPR, promotional review, data licensing terms, emerging AI regulation).
• Advanced Excel modeling plus working proficiency in Python, SQL and a visualization tool (Power BI/Tableau).
• Experience across the launch lifecycle in oncology, cell and gene therapy, rare disease or another specialty/limited-distribution setting.
• Proven ability to operate independently in a lean, fast-moving environment, and to translate complex quantitative and technical work into decision-ready recommendations for senior stakeholders.
• Direct experience forecasting an autologous CAR-T, TCR-T or other engineered cell therapy asset, including site activation and manufacturing-constrained demand models.
• Track record of standing up a forecasting or commercial AI capability at a pre-commercial or newly commercial company.
• Exposure to global forecasting and to market access/pricing analytics in specialty oncology.
• Applicants must be authorized to work in the United States without the need for current or future sponsorship.
• Employment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law. For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.

Responsibilities

• Develop Commercial AI roadmap — Serve as the Commercial team’s resident AI expert across the full commercial organization: partner with Marketing, Market Access, Medical Affairs and Field Operations to identify, prioritize and sequence high-value AI and generative-AI use cases — analytics and forecasting, market research synthesis, competitive intelligence, field enablement, content development and promotional review preparation, account and KOL intelligence, payer and policy monitoring, and CRM data quality — with a clear view of business impact, effort and sequencing.
• Build the operating systems — Design, build and own AI-powered systems that become how Commercial runs day to day — not one-off pilots. Re-engineer the analytics workflow end to end so recurring work runs itself: automated ingestion and QC of claims, specialty distributor, CRM and third-party data; reconciliation and exception flagging; forecast and dashboard refreshes; self-service analytics layers; recurring report and insight generation; and agentic workflows that take manual assembly off the critical path — shifting the team’s time from producing numbers to interpreting them.
• Build vs. buy and vendors — Evaluate AI platforms and vendors, run structured pilots against defined success criteria, and make defensible build-versus-buy recommendations.

Benefits

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars
• 100% employer-paid short- and long-Term disability coverage
• 401(k) with immediate eligibility and company match.
• Partially paid parental leave for eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior