Senior Director, Clinical Translational Scientist

Repertoire Immune Medicines•Watertown, MA

2d•$260,000 - $315,000

About The Position

Repertoire Immune Medicines is seeking a seasoned, immunology-focused pharmacology leader to shape and advance a portfolio of T cell-targeted therapies in oncology and autoimmune disease. Reporting to the SVP of Integrated Therapeutic Engineering and Development, this leader will guide development-stage research strategy and execution, advancing programs from discovery through IND-enabling studies. The role calls for deep scientific expertise and decisive leadership to define mechanisms of action, establish PK/PD and efficacy relationships, and translate T cell engager and mRNA/LNP modalities into clinically actionable programs. The successful candidate will integrate work across discovery, platform, and development functions and influence portfolio direction and execution to advance differentiated T cell-based therapies. Repertoire Immune Medicines is a clinical-stage biotechnology company developing immune-based therapies for cancer and autoimmune disease. The company uses its DECODE platform, which maps interactions between T cell receptors and antigen targets, and combines protein engineering with artificial intelligence and a proprietary database of more than one billion TCR-antigen interactions. Its lead oncology program, RPTR-1-201, is in a Phase 1/2 trial across multiple solid tumor indications. The company is based in Watertown, Massachusetts, and Zurich, Switzerland.

Requirements

PhD, MD, or MD/PhD in Immunology or a related discipline.
Expertise in developing and executing translational medicine and biomarker strategies across clinical development programs.
Proven ability to integrate scientific, biomarker, and clinical data to deepen understanding of patient populations and drug mechanisms of action in patients.
Experience leading and influencing cross-functional teams across Research, Clinical Development, and Regulatory Affairs.
Demonstrated success supporting oncology programs from early clinical development through proof-of-concept and late-stage studies.

Nice To Haves

Advanced clinical development and translational medicine expertise is strongly preferred.

Responsibilities

Lead development and execution of integrated translational medicine strategies across clinical development programs.
Develop and refine biomarker and clinical pharmacology plans supporting target engagement, proof-of-mechanism, proof-of-biology, dose optimization, and patient selection.
Translate biological, pharmacological, and clinical data into actionable development recommendations.
Identify and prioritize translational milestones for portfolio decisions and stage-gate transitions.
Define strategies for exploratory, pharmacodynamic, predictive, prognostic, and diagnostic biomarkers.
Partner with bioanalytical and laboratory teams to develop, validate, and implement clinical biomarker assays.
Interpret biomarker, PK/PD, and clinical datasets to generate insights about mechanism of action, treatment response, and resistance pathways.
Support implementation of innovative technologies and emerging translational approaches.
Contribute to study design, protocol development, endpoint selection, statistical analysis planning, and clinical study execution.
Build productive relationships with internal stakeholders, external partners, CROs, academic investigators, key opinion leaders, and laboratory vendors.
Contribute translational components to regulatory submissions, including INDs, briefing documents, and marketing applications.
Support health authority interactions related to biomarkers, companion diagnostics, and translational strategy.
Monitor scientific advances and competitive developments in oncology, immunology, and related therapeutic areas.
Foster a collaborative, patient-focused, and scientifically rigorous culture.
Contribute to departmental strategy, capability building, and organizational development.