Senior Director, Clinical Scientist

Madrigal Pharmaceuticals•Conshohocken, PA

8d•$260,000 - $318,000

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Senior Director, Clinical Scientist, will support the development and execution of clinical trials for assets targeting Metabolic dysfunction-associated steatohepatitis (MASH). Reporting to the VP of Clinical Development, this role will help drive the scientific strategy, clinical trial design, and data interpretation for one or more programs in the MASH portfolio. The ideal candidate has experience in clinical development, a strong understanding of clinical trial execution, and a passion for advancing therapies in liver and metabolic diseases. This position will require close collaboration with cross-functional teams and external partners to ensure scientific rigor and high-quality clinical data.

Requirements

Advanced degree (PhD, MD, PharmD, or equivalent) in a life sciences field required; Master’s with relevant experience may be considered.
10+ years of experience in clinical development or clinical research within the pharmaceutical or biotechnology industry.
15+ years relevant experience.
Solid knowledge of ICH/GCP and global clinical trial regulations.
Demonstrated ability to synthesize complex scientific data and present it clearly and effectively.
Excellent verbal and written communication skills.
Collaborative mindset with strong organizational and project management abilities.

Nice To Haves

Prior experience in liver disease, metabolic disorders, or MASH/NASH strongly preferred.
Experience working in a fast-paced biotech environment with small, agile teams.
Familiarity with liver disease endpoints such as histology, imaging, or non-invasive biomarkers.
Experience supporting regulatory interactions or submissions is a plus.

Responsibilities

Providing strategic and scientific leadership across clinical programs, driving study design, execution, and cross-functional alignment to advance assets through development and toward regulatory milestone
Contribute to the design and development of clinical trial protocols, including scientific rationale, study objectives, endpoints, and eligibility criteria.
Author or review key clinical documents such as investigator brochures, informed consent forms, clinical study reports (CSRs), and regulatory submissions.
Provide scientific input during trial execution, including protocol amendments, site engagement, data reviews, and ongoing study support.
Collaborate with clinical operations, data management, biostatistics, and medical writing to ensure high-quality trial conduct and data integrity.
Conduct data reviews and support data interpretation in collaboration with biostatistics and the medical team.
Support the preparation of documents for regulatory submissions, health authority meetings, and internal governance presentations.
Stay current on therapeutic area trends, competitive landscape, and regulatory guidance related to MASH/NASH and associated comorbidities.
Participate in cross-functional meetings and contribute to development strategies and timelines.