Senior Director, Clinical Science

CytomX Therapeutics, Inc.•Emeryville, CA

58d•$260,000 - $330,000•Hybrid

About The Position

About CytomX Therapeutics: CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel PROBODY® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX’s robust and differentiated pipeline comprises therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engagers, and immune modulators such as cytokines. CytomX’s clinical-stage pipeline includes CX-2051 and CX-801. Learn more at www.cytomX.com. Who You Are and What You’ll Do: You are passionate about life sciences and making a difference to cancer patients, their families, and healthcare providers. As Senior Director, Clinical Science, you will provide strategic and scientific leadership for one or more oncology programs spanning early- through late-stage clinical development. You will collaborate across functions to translate emerging safety, efficacy, pharmacology, biomarker, and operational data into clear recommendations that advance clinical strategy and study execution. Your immediate priorities will include leading integrated clinical data review for assigned studies, strengthening scientific interpretation and decision-making, supporting high-quality study execution, and preparing clinical-science deliverables for upcoming development and regulatory decisions.

Requirements

MD, PharmD, PhD, or an equivalent advanced degree in medicine, pharmacy, life sciences, or a related discipline.
At least 10 years of relevant biotechnology or pharmaceutical industry experience, including at least 7 years of direct clinical-development experience. An equivalent combination of education and experience may be considered.

Nice To Haves

Clinical-development experience in oncology, including meaningful experience with the design, execution, analysis, and interpretation of interventional clinical studies.
Demonstrated ability to lead complex clinical-science deliverables and influence multidisciplinary stakeholders in an individual-contributor capacity.
Experience integrating clinical safety, efficacy, pharmacology, biomarker, and operational information into scientifically grounded development recommendations.
Strong knowledge of clinical trial methodology, clinical data review, scientific documentation, and applicable regulatory and quality expectations.
Experience developing or contributing to protocols, clinical study reports, regulatory documents, or other major clinical-development deliverables.
Ability to communicate complex scientific and clinical information clearly, concisely, and persuasively to technical and nontechnical audiences.
MD or MD/PhD with relevant oncology clinical-development experience.
Experience spanning both early- and late-stage oncology clinical development.
Experience contributing to regulatory interactions, clinical-development plans, or major regulatory submissions.
Experience supporting dose optimization, benefit-risk assessment, and development of clinical data-review strategies.
Experience integrating biomarkers, translational findings, or patient-selection strategies into clinical-development decisions.
Experience with antibody-drug conjugates, T-cell engagers, immuno-oncology agents, cytokines, or other complex oncology therapeutic modalities.
Experience supporting global or multicenter clinical studies.
Experience presenting clinical data to governance bodies, investigators, regulatory authorities, or external scientific audiences.
Experience coaching and mentoring clinical-science colleagues.
Experience working effectively in a collaborative biotechnology environment with evolving priorities and resource constraints.

Responsibilities

Provide scientific leadership for the design, execution, interpretation, and communication of clinical studies across Phase 1 through Phase 3 oncology development programs, based on assigned program needs.
Lead the development and review of protocols, protocol amendments, investigator materials, clinical study reports, regulatory content, and internal clinical-development materials.
Integrate efficacy, safety, pharmacokinetic, pharmacodynamic, biomarker, and operational data to identify trends, risks, opportunities, and implications for clinical strategy.
Lead ongoing clinical data review in collaboration with Clinical Operations, Biostatistics, Data Management, Pharmacovigilance, Regulatory Affairs, Translational Medicine, and other relevant functions.
Develop and clearly communicate scientifically grounded recommendations regarding study design, patient populations, endpoints, dose and schedule, data analyses, and future development options.
Serve as a senior Clinical Science representative on study and program teams, facilitating alignment, timely decisions, and clear accountability.
Anticipate complex clinical-program risks, convene the appropriate stakeholders to evaluate options, and recommend a timely path forward.
Contribute to clinical-development plans and short- and long-range program strategy based on emerging evidence, the evolving treatment landscape, and patient needs.
Support interactions with investigators, external experts, partners, vendors, and regulatory authorities, as appropriate.
Communicate complex clinical and scientific information clearly to executive leaders, governance bodies, cross-functional teams, investigators, and other external audiences.
Coach and mentor clinical scientists and other colleagues through scientific expertise and cross-functional leadership, without direct people-management responsibility.
Maintain current knowledge of oncology standards of care, emerging scientific evidence, the competitive landscape, and applicable regulatory guidance.
Perform responsibilities in accordance with applicable regulations, quality standards, company policies, and ethical requirements.