Senior Director, Clinical Development

AVENZO THERAPEUTICS INC•San Diego, CA

10h•$332,000 - $360,000•Hybrid

About The Position

Avenzo Therapeutics, Inc., a clinical-stage biotechnology company focused on developing next-generation oncology therapies, is seeking a Senior Director, Clinical Development. Reporting to the Vice President, Clinical Development, this role provides critical input into the strategy, development, management, and implementation of clinical studies. The Senior Director works across the clinical organization and leads multidisciplinary teams guiding clinical development and regulatory submissions. The role provides medical and scientific oversight for assigned oncology programs, including clinical studies, operational staff, CROs, and trial sites. It leads clinical and regulatory document development and review, clinical data analysis and communication, safety oversight, and contributions to regulatory strategy and health authority engagement. The Senior Director also builds relationships with investigators and key opinion leaders, mentors cross-functional teams, and supports publications and global submissions. The position is full-time and may be based in San Diego or remotely within the U.S. Remote employees are expected to travel to and work from the San Diego headquarters from time to time. San Diego-based employees are expected onsite Monday through Thursday. Regular or periodic travel may account for up to 15% of work time and may include overnight travel.

Requirements

MD required.
10+ years of experience in the life sciences industry, or an equivalent combination of academic and industry experience.
Oncology solid tumor clinical development experience.
8+ years of experience in clinical development.
Proven track record of leading clinical development programs from early-phase trials through regulatory submissions.
Strategic leadership skills, including the ability to inspire, mentor, and manage cross-functional teams.
Ability to excel in a fast-paced, entrepreneurial environment and adjust priorities in response to changing business needs.
Excellent communication and interpersonal skills, with the ability to collaborate effectively with internal and external stakeholders.
Strong analytical and problem-solving abilities, with a strategic mindset.
Ability to travel periodically or regularly, up to 15% of work time, potentially including overnight travel.

Nice To Haves

Advanced degree in medicine, life sciences, or a related area.

Responsibilities

Lead the development, review, and approval of clinical and regulatory documents, including protocols and investigator brochures, and participate in writing and reviewing study reports and other clinical documents.
Provide medical and scientific oversight for assigned oncology programs, operational staff, CROs, and clinical trial sites.
Serve as a clinical subject matter expert for internal teams, investigators, and external stakeholders supporting the assigned solid tumor program.
Establish and approve scientific methods for the design and implementation of clinical protocols, data collection systems, and final reports.
Provide medical and safety oversight for clinical studies, including SAE review, safety signal evaluation, and participation in safety governance activities.
Lead the analysis, interpretation, and communication of clinical data to support development, regulatory, and portfolio decision-making.
Build and maintain relationships with principal investigators and key opinion leaders to support clinical development programs.
Contribute clinical expertise to regulatory strategy and health authority engagements, supporting major regulatory submissions and development milestones across the product lifecycle.
Provide scientific leadership, guidance, and mentorship to cross-functional clinical teams on medical, scientific, and therapeutic area topics.
Lead the preparation and review of clinical study reports and other regulatory documents to support global submissions.
Partner collaboratively with clinical operations, safety, biometrics, regulatory, medical writing, and medical affairs to advance programs and support business objectives.
Serve as a therapeutic area subject matter expert and present clinical and scientific data to internal and external stakeholders.
Support publication strategy and the development and review of publications.

Benefits

Medical, dental, vision, and basic life and AD&D insurance for eligible employees and dependents.
Short-term and long-term disability insurance.
Flexible spending accounts and health savings accounts.
Voluntary insurance programs, including voluntary life, AD&D accident, and critical illness insurance.
401(k) plan.
Accrual of 10 hours of paid vacation time per month.
Accrual of 1 hour of paid sick leave for every 30 hours worked.
17 paid holidays each calendar year, including a winter closure, subject to company policies.
Eligibility for an annual discretionary bonus.
Eligibility for an equity award.