Senior Director, Advanced Analytics Products

Madrigal Pharmaceuticals•Waltham, PA

About The Position

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Senior Director, Commercial Advanced Analytics is the senior commercial-domain expert for advanced analytics and AI, translating deep knowledge of the Commercial business into high-value use cases and the requirements behind them. Reporting to the Executive Director of Data Strategy & Analytics, this leader works directly with Commercial leadership and functions to identify and prioritize high-value use cases, define the business requirements and success measures, and partner with the enterprise AI team — which builds, deploys, and governs the underlying models and AI capabilities — to embed them in commercial workflows and drive adoption. This role is focused on identifying, prioritizing, and being the “business owner” of Commercial advanced analytics / AI initiatives and products with a focus on enabling accelerated insights, optimizing workflows, and driving the ideation and adoption of critical capabilities. The enterprise IT AI team will be responsible for the hands-on build of these capabilities and deployment. Together, this partnership will deliver on accelerating Madrigal's Commercial success.

Requirements

Bachelor's degree in a quantitative field such as statistics, data science, computer science, or engineering; advanced degree (MS or PhD) preferred.
15+ years in pharmaceutical or biotech commercial advanced analytics, with demonstrated value generation across Sales, Patient Services, Market Access, and Marketing (e.g., omni-channel, attrition modeling, shareshift)
Fluency with core commercial data assets — specialty pharmacy / hub, claims (e.g., IQVIA, Symphony), CRM / Veeva, call and activity, and consent data — and the governed semantic layer built on them.
Experience partnering with technical teams to bring machine learning and AI-driven tools into production commercial workflows, with working knowledge of MLOps and model lifecycle management.
Demonstrated experience building, leading, and developing analytics or data science teams.
Hands-on proficiency in Python and SQL, and experience with cloud data and machine learning platforms (e.g., Databricks, Fabric, Azure/AWS ML tooling).
Deep fluency in the commercial operating model (field and home-office orchestration, market access, brand performance, patient services workflow optimization), paired with strong technical grounding and the judgment to prioritize high-ROI use cases.
Ability to build trust and evaluation rigor around new AI capabilities with non-technical stakeholders.
Effective cross-functional partnership across Commercial, Medical, IT, and the enterprise AI team, including translating business needs into technical requirements.
Proven people leadership and team development.

Nice To Haves

Experience applying evaluation and phased-rollout approaches (e.g., shadow-mode) for AI tools deployed on an enterprise platform.
Experience supporting specialty or rare disease brands.
Proven success in deploying AI workflow enhancements with focus on RoI

Responsibilities

Serve as Commercial PoC in defining and prioritizing the roadmap of commercial advanced analytics and AI use cases, in partnership with Commercial leadership and the enterprise AI team, which builds and deploys them on the enterprise platform
Own the advanced analytics roadmap and business integration of our next-best-action / omni-channel strategy with a focus on improving our customer engagement model through field and home office orchestration
Prioritize and manage the Commercial advanced-analytics and AI use-case pipeline, aligned to the enterprise intake, prioritization, and governance process
Define the business, data, and success requirements for Commercial models and AI tools, and partner with enterprise AI and IT in deployment and optimization of these tools
Provide commercial validation and business acceptance during enterprise-run testing and phased roll-outs, applying the enterprise evaluation framework and feeding Commercial requirements back to the enterprise AI
Own the day-to-day advanced analytics operations by serving as intake for Commercial leadership requests, structuring problem statements, working with our Enterprise AI team's dedicated Commercial Analytics AI resources to build appropriate solutions, and synthesizing these results into business-facing insights
Develop requirements to our Commercial Data Products team for enhancements to our semantic layer that enables trusted self-service, democratization of model outputs, and forward-looking natural-language querying
Serve as the Commercial-domain expert who translates business needs into advanced analytics and AI solutions, and represent Commercial requirements in the enterprise AI tool vendor evaluations