Senior Clinical Trial Manager (Contract)

Centessa Pharmaceuticals•Boston, MA

6d•Remote

About The Position

Centessa Pharmaceuticals is seeking a contract-to-hire Senior Clinical Trial Manager (Sr. CTM) to lead the execution of global clinical studies from startup through closeout and clinical study report. This role is a temporary position with the potential to convert to a permanent role, accountable for study delivery, including operational strategy, timelines, budget, quality, vendor oversight, risk management, and inspection readiness. This individual will lead cross-functional teams and manage CROs and external vendors to ensure studies are conducted efficiently, compliantly, and in alignment with program objectives.

Requirements

Bachelor's degree in a scientific, health-related, or equivalent discipline required.
8+ years of clinical research experience, including 5+ years of clinical trial management experience within a sponsor or CRO environment.
2+ years of managing Phase 1 Healthy Volunteer studies.
Experience in standard clinical pharmacology package studies such as: First in Human, Drug to Drug Interaction, Human Absorption, Metabolism, Excretion and Mass Balance, Relative Bioavailability, Bioequivalence, Organ Impairment, Abuse Liability studies.
Demonstrated experience independently leading Phase 1 studies, global Phase II and/or Phase III clinical trials.
Experience managing CROs, CRUs, central vendors, and cross-functional study teams.

Nice To Haves

Neuroscience/CNS clinical development experience preferred.
Experience supporting inspection readiness, audits, and regulatory interactions preferred.

Responsibilities

Lead the planning, execution, and oversight of global clinical trials from startup through closeout.
Serve as the primary operational lead for assigned studies, driving cross-functional alignment and execution.
Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation plans, and key performance metrics.
Oversee CROs and external vendors to ensure delivery against scope, quality standards, timelines, and budget.
Drive critical study milestones, including site activation, enrollment, database lock, and study closeout.
Review and approve study plans, vendor deliverables, and trial documentation to ensure compliance with protocol, GCP, and regulatory requirements.
Identify operational risks and issues, implement mitigation strategies, and escalate as appropriate.
Lead study team meetings and provide regular updates to stakeholders and senior management.
Ensure Trial Master File (TMF) quality, completeness, and inspection readiness throughout the study lifecycle.
Support regulatory submissions, audits, inspections, and Health Authority interactions.
Contribute to process improvements and mentor junior clinical operations team members as needed.
Collaborate effectively with global teams, investigators, CROs, and vendors across multiple regions.