Senior Clinical Trial Manager - Oncology (Europe)

Worldwide Clinical Trials

4d • Remote

About The Position

As a Senior Clinical Trial Manager, you will lead the delivery of critical clinical site management activities across studies and regions, helping ensure research is conducted with quality, efficiency, and compliance at every stage. Your leadership will directly support the successful execution of clinical trials and contribute to bringing new therapies to patients. In this role, you will partner closely with project management, sponsors, CRAs, and cross-functional teams to drive study performance, oversee monitoring strategies, and ensure sites are supported from qualification through closeout. You'll play a pivotal role in risk management, team leadership, operational excellence, and the delivery of high-quality clinical outcomes. You will also serve as a key point of contact for sponsors and study teams, providing strategic oversight, mentoring site management teams, and ensuring clinical operations remain aligned with study goals, timelines, and quality expectations.

Requirements

• Four-year college curriculum or equivalent with a major concentration in biological, physical or health studies and a minimum experience of 4 years as a Senior Clinical Research Associate (or equivalent), OR Two-year college curriculum or equivalent education/training (nursing degree or equivalent life science degree preferred) and a minimum experience of 6 years as a Senior Clinical Research Associate, AND Minimum 2 years relevant experience as a CTM/LCRA (or equivalent) including overseeing a CTM team.
• Experience working with Oncology studies is required for this role.
• Experience leading or coordinating clinical monitoring and site management activities within clinical trials.
• Strong understanding of clinical research principles, site management processes, and monitoring best practices.
• Knowledge of FDA and/or EU regulations, ICH Guidelines, local regulatory requirements, and clinical trial SOPs.
• Experience reviewing study metrics, managing operational risks, supporting recruitment activities, and maintaining high-quality study documentation.
• Proficiency with Microsoft Office and clinical systems including EDC, CTMS, IxRS/IVRS, and eCRF platforms.
• Demonstrated ability to lead and motivate remote teams, influence stakeholders, solve complex problems, and manage multiple priorities effectively.
• Proficiency in English, with excellent written, verbal, presentation, and interpersonal communication skills.

Responsibilities

• Lead and coordinate clinical site management activities from study startup through database lock and study closeout.
• Partner with project management to develop monitoring strategies, establish site management targets, and ensure delivery against project goals.
• Provide leadership, guidance, and oversight to CRAs and site management team members across assigned studies and regions.
• Serve as the primary site management representative for sponsors, study teams, investigator meetings, audits, inspections, and key project discussions.
• Drive quality and compliance by overseeing monitoring activities, reviewing protocol deviations, ensuring adherence to Clinical Monitoring Plans, and maintaining inspection readiness.
• Monitor study metrics, recruitment performance, resource allocation, and operational trends to identify risks and implement effective solutions.
• Support patient recruitment efforts by tracking enrollment progress and guiding site-specific recruitment strategies to maintain study targets.
• Ensure Trial Master File compliance and oversee the timely completion and quality review of site management documentation.
• Proactively identify, escalate, and mitigate operational and monitoring risks while supporting issue resolution and continuous improvement initiatives.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Associate degree