Senior Clinical Research Associate

Immatics • Houston, TX

3h • Remote

About The Position

Join Immatics and shape the future of cancer immunotherapy; one patient at a time! Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Role Overview: We are seeking a Senior Clinical Research Associate (CRA) to support our Clinical Operations team. The Senior CRA will be responsible for overseeing clinical trial site management and monitoring activities to ensure compliance with ICH-GCP, regulatory requirements, and company SOPs. In this role, you will partner closely with clinical sites and cross-functional teams to support high-quality study execution, patient recruitment, and operational excellence across clinical trials.

Requirements

• Bachelor’s degree in life sciences, nursing, or a related field
• 4+ years of on-site monitoring experience within the pharmaceutical or biotechnology industry, including all clinical monitoring visit types
• Strong knowledge of ICH-GCP, FDA, EMA, and applicable clinical trial regulations
• Demonstrated experience managing clinical trial sites, monitoring activities, and clinical trial documentation
• Proficiency with clinical trial systems and tools (e.g., CTMS, eTMF, Microsoft Office)

Nice To Haves

• Experience in oncology clinical trials or related therapeutic areas
• Advanced presentation, organizational, and stakeholder management skills
• Experience mentoring or training junior CRAs and supporting cross-functional clinical operations activities
• Demonstrated ability to drive quality, efficiency, and continuous improvement initiatives in clinical operations
• Strong understanding of clinical trial recruitment strategies, data capture, and site engagement best practices
• Experience contributing to global harmonization, process optimization, or operational innovation initiatives

Responsibilities

• Conduct all clinical monitoring activities, including site qualification, initiation, routine monitoring, and close-out visits
• Support site feasibility, site selection, and ongoing site management activities throughout the clinical trial lifecycle
• Review clinical trial progress, patient recruitment, and data quality metrics, and implement actions to support study objectives
• Maintain accurate and timely monitoring documentation, including trip reports and trial master file records
• Collaborate with vendors, clinical sites, and cross-functional teams to support study execution and operational compliance
• Participate in investigator meetings, clinical trial documentation development, and study team meetings
• Mentor junior CRA team members and contribute to continuous improvement of clinical operations processes and procedures

Benefits

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer-paid life insurance up to 1x annual salary, up to one hundred thousand dollars
• 100% employer-paid short- and long-Term disability coverage
• 401(k) with immediate eligibility and company match
• Partially paid parental leave for eligible employees.
• Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior