Senior Clinical Manager - Immunogenetics and Transplant Diagnostics (ITD)

Mass General Brigham•Boston, MA

3d•$99,632 - $126,027•Onsite

About The Position

The Immunogenetics and Transplant Diagnostics (ITD) service currently operates across two laboratory sites, one at each academic medical center. Together, the BWH Tissue Typing and MGH Histocompatibility laboratories provide comprehensive support for solid organ (kidney, heart, lung, liver, pancreas), as well as hematopoietic progenitor cell transplantation and specialized non-transplant diagnostic testing. ITD performs approximately 60,000 HLA/histocompatibility-related tests per year. Collectively, the ITD laboratories support the combined Mass General Brigham transplant programs which performed more than 750 organ transplants in 2025 alone. In addition, the MGB ITD Service serves as the Organ Procurement Organization histocompatibility laboratory for OPTN Region 1 and supports nine additional organ and HPCT transplant hospitals across New England. The senior clinical manager will partner with ITD and MGB Pathology leadership to build a fully integrated immunogenetics laboratory.

Requirements

Must meet CLIA qualifications for general supervisor for high complexity laboratory performing histocompatibility testing (CFR § 493.1461), ASHI standard E.5.1, as well as OPTN and the Massachusetts Department of Health regulations.
Progressive operational leadership experience managing large, complex histocompatibility laboratories supporting multi-hospital transplant programs and organ procurement organizations (OPO).
Knowledge of OPTN Region 1 operations is critical.
Proven success overseeing all aspects of high-volume, 24/7 laboratory operations including staffing, workflow optimization, quality management, turnaround time, regulatory compliance, competency assessment, delivery of key performance indicators (e.g. turnaround times), capital/equipment planning, and budgeting/financial stewardship.
Experience partnering with Pathology and laboratory medical and clinical leadership to support multiple transplant programs and coordinate testing and reporting urgent, time-sensitive transplant and other clinical decisions.
Exceptional communication and execution skills with demonstrated ability to communicate clearly across technical, clinical and executive stakeholders, establish accountability and ensure consistent follow-through on operational, quality and strategic priorities.
Exceptional collaboration and relationship-building skills with a track record of working effectively with external partners including transplant physicians, surgeons, clinical care teams, OPO leaders, IT, billing and compliance, quality and administrative leaders to advance laboratory operational excellence.
Demonstrated success leading process improvement, technology implementation, assay implementation/validation, and operational change within a complex clinical laboratory environment.
Broad technical expertise across the full scope of Histocompatibility testing, including: Next-generation sequencing (NGS)–based HLA typing, HLA antibody identification and characterization, Donor-specific antibody (DSA) testing, Physical (flow and CDC) and virtual crossmatching, Chimerism testing, ABO testing.
Strong experience in workforce leadership including development of sustainable staffing models, mentoring, career development, performance management, scheduling, productivity, inventory management and resource allocation.
Experience developing and maintaining comprehensive quality management systems, including proficiency testing, competency programs, corrective and preventative actions, document control and continuous improvement initiatives.
Expertise with laboratory information systems and the integration of laboratory testing platforms/instrumentation, interfaces, and information technology solutions to support complex clinical workflows.
Bachelor's Degree Laboratory Sciences required.
ASCP Certified Medical Technologist [MLT, MT, MLA, Histologists] - Generic - HR Only required.
Lab experience 5-7 years required.
Demonstrated leadership experience in hospital-based CLIA laboratory 3-5 years required.
Detailed knowledge of all regulatory requirements, including CAP, Joint Commission, and CLIA.
Expert knowledge of laboratory health and safety protocols.
Strong innovative attributes to remain on top of technology shifts.
Effective written and verbal communication skills.
Read, write and comprehend English sufficiently to communicate with patients, laboratory and others.
Strong knowledge of personnel and employment practices.
Ability to effectively manage staffing levels and workloads.
Ability to effectively interview and train new employees.

Nice To Haves

Master's Degree Related Field of Study preferred

Responsibilities

Responsible for the daily operation of the lab: staffing, workflow, quality, safety, and regulatory compliance.
Provides daily management and strategic direction for the laboratories.
Ensures compliance with all relevant federal, state, and accreditation requirements.
Oversees operations at multiple sites and requires strong management skills, as well as a collaborative approach when working with leaders both locally and within the system.
Develops and maintains QA systems to ensure a high level of performance and effective remedial actions to address deviations from performance specifications.
Reviews performance information, identifies opportunities for improvement, and takes action to eliminate root causes of performance that do not meet expectations.
Reviews event management reports, investigates complaints or problems, and analyzes data to identify trends or patterns.
Ensures a validation protocol and validation summary is created for new or changed processes.
Assigns, monitors, and supervises work to ensure compliance with laboratory SOPs and applicable federal, state, and accreditation requirements, including health/safety and patient confidentiality.
Ensures the laboratory is prepared for all regulatory reviews and inspections (e.g., TJC, CAP, FACT).
Oversees the coordination of clinical trials with principal investigators, study coordinators, quality assurance, and compliance.
Manages computer systems to access clinical laboratory results, produce worksheets on components processed, and perform other data collection or analysis activities.
Conducts interviews and recommends candidates for hiring in accordance with departmental policies to ensure adequate staffing for the laboratory.
Responsible for staff orientation, training, competency assessment, and continuing education, including required department training (safety, infection control, compliance).