Senior Clinical Data Manager

Lilly • Indianapolis, IN

5d • $115,500 - $187,000 • Onsite

About The Position

The Senior Clinical Data Manager will report to the Senior Director of Data Sciences and serve as a hands‑on contributor supporting Centessa’s clinical programs. This role is ideal for an experienced, self‑motivated clinical data professional who enjoys working closely with the data, operating with autonomy, and making a direct impact in a fast‑paced, growth‑oriented environment. The position partners cross‑functionally to support dependable, high‑quality clinical data delivery in support of key development milestones. The successful candidate brings strong technical expertise, sound judgment, and the ability to collaborate effectively across distributed teams. This is an opportunity to apply deep clinical data management experience in an entrepreneurial, collaborative culture where attention to detail, ownership, and proactive problem‑solving are highly valued.

Requirements

• Bachelor’s or Master’s degree with a minimum of 6+ years of hands‑on clinical data management experience in a pharmaceutical or biotechnology environment.
• Expert knowledge of electronic clinical data systems, including multiple vendor EDC platforms and related clinical trial technologies.
• Proven experience managing and partnering with CROs and technical vendors, including oversight of deliverables, timelines, and quality.
• Strong understanding of regulatory requirements impacting clinical data management, including experience supporting regulatory submissions; Pre‑IND, IND, NDA, and/or BLA experience strongly preferred.
• Demonstrated experience supporting multiple complex clinical studies, including early‑phase (first‑in‑human and proof‑of‑concept) trials; Phase I–III experience preferred.
• Excellent project planning and organizational skills, with the ability to prioritize competing demands, manage timelines, and deliver high‑quality work in a fast‑paced environment.
• Highly self‑motivated and detail‑oriented, with strong analytical skills, intellectual curiosity, and a proactive approach to problem solving.
• Exceptional interpersonal, communication, and presentation skills, with the ability to influence and collaborate effectively across cross‑functional teams and with external partners.
• Strong critical and strategic thinking abilities, enabling effective analysis of complex data and operational challenges.

Nice To Haves

• Experience in CNS, oncology, and/or rare disease indications is a plus.
• Phase I–III experience preferred.

Responsibilities

• Lead the planning and execution of clinical data management activities to support global development programs, ensuring high‑quality, timely, and cost‑effective delivery
• Develop and oversee data management strategies and plans, including data capture tool design, data processing, coding, validation, and ongoing data quality oversight.
• Establish and maintain clinical data systems and infrastructure, including the identification, set‑up, testing, and technical oversight of electronic clinical trial technologies (e.g., EDC, IRT, ePRO, ECG, and other external data sources).
• Drive data standards strategy and compliance, providing guidance across the data continuum and ensuring adherence to CDISC/CDASH standards to support regulatory submissions.
• Partner closely with internal stakeholders and external CRO and technology vendors to align on requirements, timelines, deliverables, and performance expectations.
• Provide oversight of vendor technology platforms and processes, ensuring they meet regulatory, quality, and inspection‑readiness requirements for global development programs.
• Develop and manage data management documentation, including data management plans, data transfer plans, and validated automated data flows for internal and external data.
• Monitor timelines, milestones, and deliverables, proactively communicating risks, metrics, and status to cross‑functional teams and leadership.
• Generate and review in‑process data reports and listings to support trial oversight and decision‑making, including safety and data review activities.
• Provide data management input into clinical and regulatory documents, including protocols, protocol amendments, clinical study reports, and statistical analysis plans.
• Ensure data integrity, quality, and regulatory compliance, supporting GCP inspection readiness across all data management domains.
• Contribute to the development of best practices, SOPs, and scalable data management processes to support a growing clinical portfolio.

Benefits

• company bonus (depending, in part, on company and individual performance)
• company-sponsored 401(k)
• pension
• vacation benefits
• medical, dental, vision and prescription drug benefits
• flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts)
• life insurance and death benefits
• certain time off and leave of absence benefits
• well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities)

What This Job Offers

• Job Type: Full-time
• Career Level: Senior