Senior Bioprocess Specialist/Engineer
About The Position
TreeFrog Therapeutics is seeking an experienced bioprocess specialist/engineer to join our discovery and innovation team in Cambridge, MA. TreeFrog is using our proprietarly C-Stem microencapsulation technology to develop advanced manufacturing solutions to enable the production of pluripotent stem cell (PSC) derived therapeutics for the treatment and cure of multiple diseases (Parkinson’s, Type 1 Diabetes, and others). The laboratory in Cambridge consists of field experts in multiple complementary technical disciplines (stem cell biology, cell differentiation, physics, microfluidics, etc.) who collaborate rapidly identify problems in the manufacturing space and develop novel solutions. We are seeking an experienced bioprocess engineer to lead a team dedicated to integrating our existing technologies and expertise and applying it to scaled biomanufacturing.
Requirements
- Bioprocess engineer with at least 3 years of demonstrated experience with perfused bioreactor systems in the 1 and 10 liter scale.
- At least 3 years demonstrated experience with pluripotent stem cells (either Embryonic or induced) and growth within a stirred tank bioreactor. Minimally must have experience with pluripotent stem cell expansion, but ideally with both expansion and differentiation.
- Experience with proper experimental design (DOE or similar) and implementation within a perfused bioreactor environment
- Experience in testing and developing novel in-process controls (capacitance sensors, metabolite sensors, etc).
- Strong experience in multiple analytical assays. Experience in flow cytometry a must.
- Experience in working in a Good Manufacturing Practice (GMP) environment, and understanding the technical constraints
- Excellent documentation skills
- Fluent in English with excellent communication skills
- Ability to simplify complex technical information and communicate to non-experts
- Ability to work limited weekend hours
Nice To Haves
- Familiarity with the Eppendorf bioreactor systems
- Experience with microfluidics and understanding the technical advantages/disadvantages
- Experience with alginate microencapsulation methods and instruments
- Familiarity in common software packages and coding languages (MatLab, Python, R, etc)
Responsibilities
- Lead a small team of bioprocess technicians/engineers to execute on experiments and foster their career development
- Work with group leaders within the Cambridge site, as well as cross-functional teams in the Bordeaux main site to develop a cohesive strategy to solve critical problems
- Execute on bioprocess experiments both internally and with external collaborators to move clinical programs forward
- Act as interface between stem cell biology, cell differentiation, and process development to design and execute on handoff strategy and clinical development program.
Benefits
- Competitive salary and bonus structure
- Medical/Dental/Vision, including HSA Plan
- 401(k) w/ employer match
- Generous PTO and leave policies
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
No Education Listed
