Senior Associate Scientist

Sanofi•Waltham, MA

1d•$75,000 - $108,333•Onsite

About The Position

We are seeking a highly motivated and scientifically rigorous individual to join the Plasmid Production Pilot team. You will focus on execution and scale-up of a robust pDNA production process focusing on bacterial cell lysis, supercoiled plasmid DNA linearization, and purification for preclinical linearized plasmid DNA production, with the ultimate goal of transferring at scale methods to either the internal or external manufacturing team for mRNA drug substance with applications towards vaccine development. Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you’ll help advance prevention on a global scale - and shape the future of immunization.

Requirements

Bachelor's OR Master's degree in Biotechnology, Chemistry, Chemical Engineering, Biomedical Engineering, or related scientific field
Bachelor's degree holders: Minimum 3+ years of relevant industry experience in pharma, biotech, or laboratory settings
Master's degree holders: Minimum 1+ year of relevant industry experience in pharma, biotech, or laboratory settings
Hands-on experience with HPLC (High-Performance Liquid Chromatography) operations
Wet lab experience, particularly with fermentation or purification processes (plasmid DNA, protein, or similar)

Nice To Haves

Hands-on experience in small- and large-scale plasmid DNA extraction and purification methodologies including alkali lysis, chromatography separation (anion exchange, hydrophobic interaction) and buffer exchange methods
Familiar with Cytiva AKTA Pilot and Repligen TFF system (K2Ri and KMPi)
Familiar with Sartorius PATfix system
Prepare buffers for purification process
Familiar with equipment setup, process troubleshooting and maintenance and experience in GLP environment is advantageous
Works collaboratively within group for improved operational excellence as well as within interdisciplinary teams
Desire to work in a team-first, fast-paced environment, learn new technologies and skills, and to efficiently solve problems
Excellent organizational and communication skills
Attention to detail & meticulous record keeping
Demonstrate continuous growth in depth and breadth of personal scientific knowledge and understanding of strategic goals of group, team, and company

Responsibilities

Evaluate, and implement purification technology and optimize existing techniques and workflows.
Support the execution and optimization of plasmid DNA purification, problem solving.
Design and execute decision-quality research; prepare/draft SOPs, technical reports, batch record, and presentations to management and other stakeholders.
Work independently, pro-actively, and be an impactful contributor to project teams. Function in highly collaborative cross functional teams.
Execute ~20 batches per year.
This will be primarily a lab-based position.