Senior Associate Scientist, Synthesis, RNA Process Sciences
About The Position
The RNA Synthesis Process Sciences role plays a central part in collaborating with research and manufacturing to define early process conditions and scale down process development. By combining deep scientific expertise with enabling technologies and strong cross-functional partnerships, RNA Process Development delivers transformative innovation across the pipeline. The Senior Associate Scientist provides scientific support for drug substance programs spanning preclinical to early-stage development across circular and linear mRNA modalities. This role encompasses hands-on contributions by driving sound experimental execution and establishing linkages from a research concept to manufacturing implementation. The candidate should be driven by developing and characterizing RNA synthesis processes for improving the yield, quality and robustness.
Requirements
- Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
- BS with 4+ years’ experience in science related disciplines
- MS with 2+ years’ experience in science related disciplines
- Knowledge of automated liquid handlers, small scale stir tank reactors, and other novel reactor designs
- Working knowledge of statistical design of experiments (DoE) and analysis of multivariate data
- Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
Nice To Haves
- Hands-on experience programming/operating liquid handling systems, high throughput workflow design, LIMS/ELN systems for sample tracking, and scripting languages for instrument control is a plus
- Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing is a plus
- Background in providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications is a plus
- Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
- Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus
Responsibilities
- Apply high throughput and data driven approaches to perform early optimization and characterization of in vitro transcription, circularization and DNase reactions
- Support the RNA drug substance synthesis process definition and scale up
- Experiment using high throughput/automated or data rich experimental setups
- Support experiments to confirm robust process performance across the control space
- Collaborate with research teams to enable quicker transitions from drug candidate nomination to clinical manufacturing
- Prepare sections of technical reports, and communicate findings internally as appropriate
- Participate in tech transfer activities to GMP manufacturing sites for RNA programs
Benefits
- wellbeing support
- retirement and financial protection benefits
- insurance offerings (medical, dental, vision, life and disability)
- Flexible Time Off (FTO)
- 11 paid company holidays
- 160 hours of paid vacation annually for new hires
- 3 optional holidays
- paid sick leave
- up to two paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
- annual Global Shutdown between Christmas Day and New Year's Day
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Associate degree
