Senior Associate Scientist - Discovery Research, Regeneron Cell Medicines

Regeneron Pharmaceuticals•Cambridge, MA

2d•$80,300 - $131,100•Onsite

About The Position

We are seeking a highly motivated and innovative Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. You will be performing immunological functional assays for analyzing genetically engineered human primary T cells (CAR-T or TCR T cells) from both early discovery programs as well as late-stage development programs' nonclinical studies that support regulatory submissions. We hope you are excited to be in a hands-on laboratory role in a fast-paced environment.

Requirements

At least a BS/MS in immunology, cell biology or related field
3+ years of relevant experience
Experience working in a biotech/pharmaceutical industry
Strong understanding of immunology and cancer biology
Extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including cell culture of primary human T lymphocytes
Experience working on in-vitro immunological studies and development of functional T cell assays using techniques such as multi-color flow cytometry, ELISA and cytotoxicity assays is required

Nice To Haves

Gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation
Experience with standard molecular biology techniques, including but not limited to PCR, qPCR, Westerns, and library preps for NGS, RNA-Seq

Responsibilities

Contributing to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications
Characterizing genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq)
Developing and performing immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR-based T-cell therapeutics
Designing experiments independently and contributing to the project direction
Maintaining an electronic lab notebook and documenting experiment results
Reviewing and presenting research data to the functional team