Scientist, Thymus-Based Therapeutics

United Therapeutics Corporation•Vancouver, BC

7d•Onsite

About The Position

United Therapeutics is a public benefit corporation focused on developing novel pharmaceutical therapies and technologies to expand the availability of transplantable organs. The company has developed six FDA-approved therapies and is working on creating manufactured organs to address the shortage of transplantable organs. The Scientist, Thymus-Based Therapeutics (Preclinical & Translational Research) will be instrumental in establishing a new research group and laboratory facility. This role involves performing preclinical and translational research, contributing directly to the preclinical development pipeline by advancing in vitro and in vivo immunology platforms. The position requires independent planning, execution, and analysis of experiments related to human thymus and T cell biology, including cell culture, isolation assays, and functional assays. The scientist will also perform multi-parameter flow cytometry, immunofluorescence staining, and contribute to the evaluation of humanized mouse models. Additionally, the role involves setting up and managing new lab spaces, coordinating with external vendors and CROs, maintaining detailed records, analyzing complex datasets, and presenting findings. The scientist will actively contribute to building a collaborative, high-performing research group within a dynamic startup culture.

Requirements

2+ years of relevant postdoctoral or industry experience with a Doctor in Philosophy (PhD) in immunology, biomedical sciences, experimental medicine, or a closely related field
Strong hands-on experience with human primary cell culture and sterile techniques
Proficiency in flow cytometry (panel design, acquisition, and data analysis)
Experience with cell isolation assays from human samples
Hands-on experience with immunofluorescence tissue staining, imaging, and analysis
Proven ability to work independently with minimal supervision, including designing, planning, executing, and troubleshooting experiments
Excellent experimental planning and strong time management skills to deliver on project timelines
Strong team player with excellent communication and collaboration skills
Highly organized, detail-oriented, and proactive

Nice To Haves

Experience planning and analyzing data from humanized mouse models
Direct experience working with thymus and T cell platforms

Responsibilities

Independently plan, execute, and analyze experiments in human thymus and T cell biology, including human primary cell culture, cell isolation assays, and in vitro T cell functional assays
Perform multi-parameter flow cytometry and analysis
Perform immunofluorescence tissue staining, imaging, and quantitative analysis
Contribute to the planning, execution, and data analysis of humanized mouse models for preclinical evaluation
Set up and help manage new lab spaces, including equipment organization, workflow development, and establishment of standard operating procedures
Coordinate effectively with external vendors, animal care facilities, and Contract Research Organizations (CROs) to support in vivo studies and data generation
Maintain detailed experimental records, analyze complex datasets, and present findings to the team
Actively contribute to building a collaborative, high-performing research group in a dynamic startup culture
Learning and contributing to preclinical models and translational research
Enthusiasm for working in a fast-paced, startup-like environment and helping establish a new research laboratory and team