Scientist/Sr. Scientist Yeast Surface Dislay

Zealand Pharma•Cambridge, MA

1d•$125,000 - $170,000•Onsite

About The Position

As a Scientist or Senior Scientist in Yeast Surface Display, you will play a central scientific role in our new Molecular Platform Development organization, driving antibody, VHH, and other mini-protein and binder discovery through yeast display technology. You will help build and operate a modern, high-throughput display platform at the inception of our new Cambridge, MA research center. This role suits a scientist with strong technical expertise across the full yeast surface display workflow, scientific curiosity, and a desire to grow in scope and responsibility.

Requirements

PhD in Protein Engineering, Immunology, Molecular Biology, Biochemistry, or a related field preferred (postdoctoral training preferred); candidates with a BS/MS and significantly more relevant industry experience will also be considered
2+ years of relevant post-degree experience in yeast surface display or related antibody/protein discovery technologies (Scientist); 4+ years (Senior Scientist)
Experience with antibody, VHH, affibody, constrained peptide, and other mini-protein or binder formats
Experience applying next-generation sequencing (NGS) to analyze display library diversity and selection enrichment; familiarity with associated bioinformatics is a plus
Familiarity with phage display or other in vitro/in vivo display technologies, and with protein expression, purification, and analytical characterization sufficient to support binder validation

Nice To Haves

Experience conducting display selections against complex targets, such as GPCRs, other multi-pass membrane proteins, or receptor complexes, is a plus

Responsibilities

Execute the full yeast surface display workflow, from library construction and transformation through magnetic bead and FACS-based selections, generating antibody, VHH, affibody, constrained peptide, and other mini-protein binders
Conduct display selections against complex and challenging targets, including GPCRs, other multi-pass membrane proteins, and receptor complexes
Design and execute affinity maturation and selection strategies to improve binder affinity, specificity, and developability
Apply next-generation sequencing (NGS) to track library diversity, monitor selection enrichment, and identify lead clones from display campaigns
Contribute to the development and application of yeast surface display capabilities within Molecular Platform Development
Partner closely with Mass Spectrometry, Biophysics, and Pharmaceutical Development colleagues to validate hit quality, sequence fidelity, and developability early in selection campaigns