Scientist / Senior Scientist, Metabolomics Group Lead

Altos Labs•San Francisco, CA

5d•Onsite

About The Position

The Mass Spectrometry Hub sits within the Institute of Technology, where we have access to an array of cutting edge instrumentation. Together we are a team with a wide variety of skills and experiences that tackle exciting challenges across all of Altos. The Scientist / Senior Scientist, Metabolomics Group Lead is responsible for end-to-end management of metabolomics and lipidomics projects, from experimental design through sample preparation, measurement, data processing and data delivery. This role partners cross-functionally with scientific and bioinformatics teams to ensure robust, reproducible data generation, maintain operational excellence of LC-MS platforms, and drive projects to successful and timely completion.

Requirements

PhD (or equivalent experience) in metabolomics, lipidomics, analytical chemistry, biochemistry, or a related discipline.
>6 years of hands-on experience with both HRAM and LRMS preferably with Orbitrap Exploris and SCIEX triple quadrupole mass spectrometry platforms.
Strong experimental design and problem-solving skills, with experience performing sample preparation of cells, tissues, and biofluids.
Demonstrated experience with mentoring and project management, including managing collaborations with scientists with diverse training backgrounds

Nice To Haves

Experience developing new methods for analysis of metabolites/lipids of interest
Prior experience in Metabolite Identification and trapping in the context of drug metabolism
Experience performing large-scale discovery studies of > 1,000 samples
Experience designing and interpreting complex isotope tracing experiments (e.g., metabolic flux analysis)
Experience integrating metabolomics/lipidomics with other omics, including proteomics and transcriptomics

Responsibilities

Collaborate with cross-functional scientists to define project objectives, assess feasibility, and establish clear deliverables and timelines
Execute and supervise sample preparation workflows for steady-state metabolomics and lipidomics
Operate, maintain, and troubleshoot LC-MS instrumentation (e.g., Thermo Exploris 240, SCIEX 7500, Vanquish HPLC) to ensure optimal performance and minimal downtime
Optimize and adapt extraction protocols to support analysis of diverse and challenging biological samples
Process and analyze raw datasets with software (e.g. Skyline, Compound Discoverer), and coordinate with bioinformatics teams to ensure accurate data processing, quality control, and efficient project execution
Maintain accurate and up-to-date project tracking and documentation in systems, such as Benchling, and shared project management tools
Communicate project status, timelines, and risks effectively to internal stakeholders and leadership