Scientist / Senior Scientist, In Vivo Cardiac Biology

Gordian Biotechnology•South San Francisco, CA

10d•$130,000 - $170,000•Hybrid

About The Position

Your primary mission as an In Vivo Cardiac Biology Scientist / Senior Scientist is to drive preclinical validation of novel therapeutic targets for heart failure, including heart failure with preserved ejection fraction (HFpEF). You will lead advanced in vivo heart failure rodent studies, perform and interpret advanced physiological analyses for therapeutic efficacy, and collaborate cross-functionally to turn screening hits into high-confidence drug discovery programs. In your first month, you'll fully onboard to our heart program launching a heart failure model development study. You will demonstrate echo image acquisition and analysis mastery across multiple views (SAX, PLAX, apical 4 Chamber) at a speed sufficient to run an active cohort. Within three months, you'll take ownership of a target validation cohort, executing echocardiography and managing weekly logistical in vivo assays. You will achieve flawless rat echo acquisition, master advanced dosing and blood draw techniques, and begin hands-on training in rat invasive hemodynamics. At the six-month mark and beyond, you'll complete your initial model studies and the first round of target validation, before launching a second validation study for the HFpEF program. Ultimately, you will drive end-to-end target development programs, including small molecule proof-of-concept studies and strategic partner collaborations, while authoring and maintaining rigorous IACUC protocols.

Requirements

PhD and/or postdoctoral training in cardiac biology, cardiac physiology, or a related field (or equivalent 4+ years of industry experience leading end-to-end research projects).
Extensive hands-on experience independently running studies in rodent models of cardiovascular disease in an academic or industry setting.
Demonstrated proficiency in rodent echocardiography (conventional short axis and auto-LV required; 4-chamber view, MV inflow, and tissue Doppler preferred) and/or invasive hemodynamics like PV loops.
Exceptional organizational skills, attention to detail, strong written and verbal communication, a collaborative approach, and the adaptability to thrive in a fast-paced environment.
Intrinsic alignment with target validation and drug discovery, alongside a genuine enjoyment of small animal physiology work.

Responsibilities

Lead advanced in vivo heart failure rodent studies.
Perform and interpret advanced physiological analyses for therapeutic efficacy.
Collaborate cross-functionally to turn screening hits into high-confidence drug discovery programs.
Launch a heart failure model development study.
Demonstrate echo image acquisition and analysis mastery across multiple views (SAX, PLAX, apical 4 Chamber).
Take ownership of a target validation cohort, executing echocardiography and managing weekly logistical in vivo assays.
Achieve flawless rat echo acquisition, master advanced dosing and blood draw techniques.
Begin hands-on training in rat invasive hemodynamics.
Complete initial model studies and the first round of target validation.
Launch a second validation study for the HFpEF program.
Drive end-to-end target development programs, including small molecule proof-of-concept studies and strategic partner collaborations.
Author and maintain rigorous IACUC protocols.