Scientist / Senior Scientist, Chemical Biology

Vividion Therapeutics•San Diego, CA

1d•Onsite

About The Position

Vividion is a next-generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first-in-class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. The successful candidate will have extensive hands-on experience and expertise in the evaluation of the impact of small molecules on protein function and stability both in vitro and in a cellular context via cell and/or biochemical assay development. This position will be responsible for leading/supporting efforts towards the validation of novel drug targets via multiple mechanisms, including testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion’s proprietary chemical proteomics platform.

Requirements

PhD and post-doc experience in biochemistry, chemical biology, cell biology or related disciplines
5+ years of post-graduate industry experience in chemistry, chemical biology or pharmaceutical chemistry
Strong molecular biology skill set (e.g., DNA cloning, site-directed mutagenesis, CRISPR, transient transfection, viral transduction, gene expression analysis)
Protein expression analysis (western blot/ ELISA/ProteinSimple)
Mammalian cell culture
Microscopy
Functional/phenotypic assays (Cell Viability 2D and 3D, Soft agar, Apoptosis)
Experience in mass spectrometry-based analyses for chemical proteomics investigations
Understanding of chemical principles and structure-activity relationships
Deep understanding of protein/ligand interactions, how to measure them, and how to characterize downstream functional effects arising from those interactions
Strong communication skills as evidenced in public presentations and/or peer reviewed literature
Effective troubleshooting and problem-solving skills
Effective team player
Strong individual contributor
Flexible
Able to handle multiple tasks and deliver high quality results under tight timelines

Responsibilities

Leading/supporting efforts towards the validation of novel drug targets via multiple mechanisms
Testing the effects of tool compounds on proteins in cellular and biochemical settings
Utilizing Vividion’s proprietary chemical proteomics platform