Scientist / Senior Scientist, Bioanalytical LC–MS – Oligonucleotide

Alloy Therapeutics • Waltham, MA

1d • $126,000 - $150,000

About The Position

We are seeking a hands-on scientist with strong expertise in LC–MS to lead bioanalytical characterization of oligonucleotide therapeutics, focusing on DMPK and biological interpretation. This LC–MS-focused role involves generating and interpreting data on oligonucleotide exposure, stability, metabolism, protein binding, and structural integrity to answer DMPK-relevant questions and link analytical findings with PK/PD and biological activity.

Requirements

• Ph.D. or M.S. in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related field.
• 3+ years (Ph.D) or 10+ years (M.S.) of post-academic experience
• Demonstrated experience with LC–MS and high-resolution MS (HRMS) oligonucleotides bioanalysis, including stability, MetID, and protein binding studies.
• Comfort working cross-functionally in a discovery environment.

Nice To Haves

• Experience with chemically modified oligonucleotides and/or conjugates.
• Ability to interpret LC–MS data in a DMPK and biological context.
• Exposure to PK/PD concepts and molecular biology-based analytical technologies (e.g., qPCR, ddPCR).

Responsibilities

• LC–MS–Driven Bioanalysis: Develop and execute LC–MS/MS and LC–HRMS methods for quantitative and structural analysis of oligonucleotides in biological matrices. Design and perform stability, degradation, and Metabolite Identification (MetID) studies to support DMPK. Provide a higher throughput or automated protein binding data (LC-MS Proteomics) .
• Exposure & Disposition: Apply LC–MS and other methods to assess oligonucleotide–protein interactions, binding, and disposition, interpreting how stability, metabolism, and chemical modifications influence systemic and tissue exposure.
• DMPK & Biological Integration: Interpret LC–MS data within a DMPK context, collaborating with cross-functional teams to link findings with PK, PD, and biological readouts (e.g., target knockdown, gene expression).
• Data Analysis & Communication: Perform quantitative LC–MS data analysis, troubleshoot analytical issues, and clearly communicate analytical and DMPK insights to inform decision-making.

Benefits

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match
• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level
• Education Level: Ph.D. or professional degree
• Number of Employees: 1-10 employees