Scientist - Rare Disease Biology

Amgen • South San Francisco, CA

2d • $123,053 - $166,483

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Scientist - Rare Disease Biology. What you will do. Let’s do this. Let’s change the world. In this vital role you will contribute to the discovery and advancement of innovative therapies for rare diseases as a core member of multidisciplinary, disease-focused research teams. You will apply experimental and data-driven approaches to investigate disease mechanisms, evaluate novel therapeutic targets, and generate insights that inform scientific and portfolio decisions. This role offers the opportunity to work at the intersection of autoimmune disease biology, fibro-inflammatory mechanisms, tissue remodeling, human disease data, and emerging technologies within a highly collaborative and scientifically rigorous environment.

Requirements

• Doctorate degree OR Master’s degree and 2 years of relevant scientific research experience OR Bachelor’s degree and 4 years of relevant scientific research experience

Nice To Haves

• Expertise in one or more areas relevant to fibroblast biology, stromal cell biology, tissue remodeling, fibrosis, extracellular matrix biology, inflammation, or fibro-inflammatory disease.
• Experience investigating cellular and molecular mechanisms that drive tissue inflammation, remodeling, and pathological structural changes.
• Demonstrated expertise in designing and executing cell-based, molecular, and biochemical assays to interrogate complex disease biology and therapeutic hypotheses.
• Hands-on experience with primary human cells, fibroblast systems, tissue-derived cultures, organoids, or other advanced in vitro/ex vivo disease models.
• Strong understanding of biological pathways involved in fibroblast activation, extracellular matrix regulation, fibrosis, wound healing, inflammation, and tissue remodeling.
• Experience applying multi-omics data or other data-rich approaches to characterize cellular phenotypes and disease mechanisms.
• Strong quantitative and data-analysis skills, with demonstrated ability to interpret complex biological datasets and translate findings into testable hypotheses.
• Experience integrating experimental data with human genetics, omics, clinical data, and scientific literature to generate mechanistic and translational insights.
• Ability to combine experimental and computational approaches to solve complex biological questions and support target evaluation.
• Scientific curiosity and demonstrated ability to rapidly learn new disease areas, biological systems, technologies, and analytical approaches.
• Ability to work effectively in collaborative, multidisciplinary, and matrixed research environments.
• Excellent written and verbal communication skills, with the ability to communicate complex scientific concepts clearly to diverse audiences.
• Ability to balance scientific rigor, urgency, and adaptability in a dynamic research environment.
• Demonstrated commitment to teamwork, knowledge sharing, and continuous improvement.
• Familiarity with AI-enabled scientific tools, computational workflows, image analysis, automation, or advanced data analytics is desirable.

Responsibilities

• Design, execute, analyze, and interpret in vitro and ex vivo studies to investigate disease mechanisms and evaluate therapeutic hypotheses.
• Generate high-quality, reproducible experimental data to support target identification, validation, and progression of rare disease research programs.
• Investigate biological mechanisms relevant to Thyroid Eye Disease (TED), including immune dysregulation, fibroblast activation, inflammatory signaling, extracellular matrix regulation, and tissue remodeling.
• Integrate experimental findings with scientific literature, human genetics, clinical observations, and multi-omic datasets to develop mechanistic insights and inform scientific decision-making.
• Develop and implement innovative experimental approaches that enhance scientific rigor, efficiency, and translational relevance.
• Collaborate closely with disease biologists, computational scientists, translational researchers, and other partner functions within multidisciplinary research teams.
• Contribute data-driven insights and recommendations to scientific discussions, target reviews, program strategy, and portfolio evaluations.
• Build productive relationships with internal and external collaborators, including academic investigators, foundations, CROs, and scientific experts, as appropriate.
• Communicate scientific findings, interpretations, and recommendations effectively to project teams, governance forums, and departmental audiences.
• Maintain accurate experimental documentation and contribute to organizational knowledge sharing.
• Foster a culture of scientific curiosity, collaboration, continuous learning, and operational excellence.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree