Scientist, Process Development (In-Vivo Upstream)

Kite Pharma•Philadelphia, PA

7d•$133,195 - $172,370•Onsite

About The Position

The Scientist, Process Development (In-Vivo Upstream) role designs and executes cell culture/upstream experiments to support development of manufacturing processes for Lentivirus. This role applies advanced chemistry, biochemistry, and/or engineering principles to deliver robust, scalable processes, supports manufacturing activities and process optimization at scale, and operates with broad autonomy and limited oversight. The Scientist is accountable for end-to-end process performance, scientific soundness, and technical leadership while training and mentoring colleagues.

Requirements

Must have strong scientific understanding and demonstrated hands-on proficiency of cell culturing methods of mammalian cells in flasks and bioreactors
Must have demonstrated hands-on proficiency
Sound understanding of bioprocess scale-up principles
Working knowledge of cGMP principles
Proficiency in Microsoft Word, Excel, Power Point, and data analysis software such as JMP, GraphPad
Proven ability to collaborate in a dynamic team environment
Excellent interpersonal, verbal, and written communication skills
Strong organization and problem-solving skills with excellent attention to details

Nice To Haves

Prior experience with process development of viral vectors
Prior experience with the use of Design of Experiments (DOE) to support process development experiments.
Prior experience with downstream and analytics of large biomolecules
Hands-on experience with large scale bioprocessing in either non-GMP or GMP setting
Demonstrated mentorship and team leadership

Responsibilities

Design and optimize scalable, safe, and cost-effective cell culture/upstream process for Lentivirus manufacturing.
Develops technical solutions to complex problems requiring ingenuity and creativity, applying advanced scientific/engineering principles to ensure scientific soundness and performance.
Supports manufacturing activities and process optimization at scale, contributing technical expertise to improve process performance and scalability.
Manages day-to-day laboratory operations, including planning work, maintaining efficient lab execution, and ensuring effective documentation practices.
Keep accurate, detailed laboratory records and comply to all required training and safety guidelines.
Apply statistical methodologies and basic modelling approaches to design experiments, perform data analysis, and interpret data.
Trains, guides, and mentors colleagues by sharing technical skills, coaching on process execution, and troubleshooting, and strengthening team capability.
Communicates technical outcomes in technical reports and presentations
Interface with multidisciplinary groups to solve complex issues and promote collaboration.
Works independently with broad autonomy and limited oversight; determines approaches for moderately complex assignments under minimal direction.