Scientist/Principal Scientist- (Multiple Sclerosis)

Genentech • Daly City, CA

4d • $120,700 - $262,900 • Onsite

About The Position

The Translational Medicine department at Genentech provides translational research to inform clinical development in disease areas of Ophthalmology, Metabolism, Neuroscience, Immunology and Infectious Diseases (TM-OMNI). Our research encompasses cutting edge support of clinical biomarker discovery and development, development of personalized healthcare strategies, and clinical translational research to study the molecular and cellular pathways driving disease to generate novel target and biomarker approaches. We are seeking a highly motivated Senior Scientist or Principal Lab Group Head to join TM-OMNI to drive biomarker and drug development and/or translational research efforts in multiple sclerosis. Our department is responsible for identifying novel approaches to treat MS using clinical translational research; designing, implementing, and interpreting biomarker results; and establishing new ways to speed clinical development in MS through biomarkers. Our group uses relevant human clinical samples and deep molecular and cellular phenotyping approaches to evaluate disease heterogeneity and disease modification by therapeutics to guide assessment of disease pathogenesis and drug discovery and development. Lab Group Heads within the department provide scientific leadership of novel projects to target unmet need in disease, and discover or develop biomarkers to advance clinical trial development.

Requirements

• PhD in Neuroscience and/or Immunology, or a related field with at least 3 years post-doctoral experience in basic or translational research either in an academic and/or industry setting.
• Demonstrate a high level of independence and must be able to develop hypotheses, direct lab scientists, and develop computational strategies to support analysis and interpretation.
• Strong writing and communication skills are required, as evidenced by publications, meeting abstracts and/or drug development reports.
• Willingness to collaborate across time zones including our Swiss site is a must.
• A demonstrated ability to function as part of a cross-functional team such as research or clinical trial project teams.

Nice To Haves

• Prior experience in multiple sclerosis preferred
• Familiar with molecular/immunological techniques and analytic methods including immunoassay, qPCR, complex in vitro modeling systems, functional genomics, genomic sequencing, scRNA-seq, TCR-seq, CITE-seq or spatial transcriptomics and/or computational methods/analytics (knowledge of R or Python)
• Candidates should have a record of mentorship (direct reports, students, interns)
• Candidates will be passionate about using their understanding of disease biology to make impactful contributions to clinical drug development

Responsibilities

• Working to identify new targets and biomarkers in support of drug development projects in multiple sclerosis.
• Leading efforts to support clinical trials, lead data generation and analyses within internal studies, and/or lead external academic collaborations relating to understanding disease pathogenesis in multiple sclerosis.
• Designing, implementing, and interpreting biomarker results.
• Establishing new ways to speed clinical development in MS through biomarkers.
• Providing scientific leadership of novel projects to target unmet need in disease, and discover or develop biomarkers to advance clinical trial development.
• Providing effective communication with presentations at cross-functional teams, internal review committees, and external conferences: and writing biomarker sections of clinical protocols, reports, regulatory filings and scientific publications.

Benefits

• Discretionary annual bonus may be available based on individual and Company performance.
• This position also qualifies for the benefits detailed at the link provided below.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree