Scientist, Preclinical

Terrestrial Bio • Woburn, MA

23h • $110,000 - $130,000 • Onsite

About The Position

Terrestrial is transforming the delivery of next-generation therapies, starting with GLP-1. Terrestrial's proprietary Tacterra™ microarray patch (MAP) and applicator platform consists of a patch resembling an adhesive bandage, which is applied with a preloaded applicator and removed after a few minutes. Once applied, each patch delivers bioactive tips into the skin, which dissolve quickly into the body, rapidly releasing their therapeutic payload. Designed for self-administration, the temperature-stable Tacterra™ platform enables precise, controlled delivery of a wide range of therapeutics without medical sharps or refrigeration. Terrestrial has generated strong clinical and in-vivo proof of concept across multiple molecules.

Requirements

• PhD in Biomedical Engineering, Pharmacology, or a related field with 2+ years of relevant experience.
• Demonstrated experience with noncompartmental PK analysis and statistical analysis of biological variability.
• Experience designing in vivo studies, including endpoint selection and determining group sizes.
• Hands-on experience with tissue mechanical testing, ex vivo tissue models, or related characterization methods.
• A record of clear technical writing, such as study reports, publications.
• Ability to present data and recommendations clearly to both scientific and non-scientific audiences.

Nice To Haves

• Industry experience is preferred; postdoctoral experience will be considered.
• Programming in R or Python, Phoenix WinNonlin, experience with transdermal, intradermal, or microneedle delivery, and exposure to IND-enabling work.

Responsibilities

• Author in vivo and ex vivo study designs and protocols, defining endpoints, group sizes, sampling schedules, and analysis plans.
• Lead the design and analysis of skin property studies.
• Quantify animal-to-animal and study-to-study variability, identify where it comes from, and recommend design changes that reduce it.
• Perform noncompartmental PK analysis and statistical analysis of study data, and present findings to the program team.
• Write study reports and technical summaries, and contribute to the nonclinical sections of regulatory documents.
• Provide scientific oversight of studies in progress, working with the in vivo team and study manager to keep execution aligned with the design.
• Bring preclinical data and interpretation to Formulation, Device Engineering, and Analytical, and contribute to broader company efforts as priorities require.

Benefits

• The anticipated base salary range for this position is $110,000 - $130,000. Actual compensation will be determined based on a variety of factors including experience, qualifications, and internal equity.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree