Scientist, Pre-Clinical Biomarkers and Translational Research
About The Position
In the role of Scientist, Preclinical Biomarkers and Translational Research, you will join the Bioanalytical Sciences group to advance novel biologic programs from pre-clinical to clinical development. You will partner closely with Biology, Toxicology, and other cross-functional teams to translate biological questions into biomarker strategies; design and execute hypothesis-driven studies; develop fit-for-purpose assays; analyze preclinical samples; and interpret results in the context of TGF-beta superfamily biology, mechanism of action, PK/PD, efficacy, and safety. This is a highly hands-on research position requiring strong scientific judgement, rigorous experimental design, excellent bench and in vivo skills, and clear communication of actionable conclusions.
Requirements
- Strong research ability, including hypothesis generation, experimental design, assay troubleshooting, and critical data interpretation
- Good understanding of TGF-β superfamily biology, related signaling pathways, and their roles in disease mechanisms.
- Hands-on experience within vivo models, tissue collection and processing, and preclinical sample analysis.
- Technical expertise in relevant methods such as ELISA, MSD, qPCR, Western blotting, flow cytometry, and mammalian cell culture, and experience developing and optimizing biomarker assays.
- Strong quantitative analysis and data visualization skills using GraphPad Prism, FlowJo, or comparable software, with careful attention to reproducibility and data integrity.
- Strong collaboration, scientific communication, documentation, and data-presentation skills.
Nice To Haves
- Experience supporting biologic drug-discovery programs.
- Experience applying TGF-beta pathway biology to preclinical, target validation, mechanism-of-action, or biomarker studies.
- Experience with MSD, Luminex, multiplex assays, flow cytometry.
- Experience with primary cells, ex vivo assays, gene perturbation, or novel disease-model development.
Responsibilities
- Partner with Biology, Toxicology and other cross-functional teams to identify critical biological questions and establish biomarker strategies for target engagement, pharmacodynamic activity, efficacy, disease biology, and potential safety findings.
- Independently generate scientific hypotheses and design, execute, and interpret in vitro, ex vivo, and in vivo studies that clarify mechanism of action and support program decisions.
- Develop, optimize, qualify, and troubleshoot fit-for-purpose biomarker assays using relevant platforms such as ELISA/MSD, qPCR, Western blotting, immunoprecipitation, multicolor flow cytometry, and cell-based assays.
- Perform hands-on analysis of serum, plasma, tissue, and cellular samples from preclinical studies, including tissue processing, tissue dissociation, primary cell isolation, and ex vivo functional analyses.
- Evaluate commercial kits, antibodies, reagents, and assay platforms; develop custom methods when needed; and ensure assay performance, reproducibility, data integrity, and appropriate documentation.
- Present study designs, data, interpretations, limitations, and recommendations at project team meetings and contribute to study reports, technical documents, publications, and patent-related activities.
- Support assay transfer and external CRO activities under the guidance of the Director of Bioanalysis, as needed.
Benefits
- Keros is an inclusive company. We believe that diversity drives innovation. We continue to build an inclusive culture that encourages, supports, and celebrates the diverse voices of our employees. As such, Keros takes a holistic approach in mentoring, coaching, and developing all of our Keros team members.
- Keros Therapeutics is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex including sexual orientation and gender identity, national origin, disability, protected veteran status, or any other characteristic protected by applicable federal, state, or local law.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
