Scientist, Pharmacokinetics
About The Position
The Drug Metabolism and Pharmacokinetics (DMPK) group within the PDMB function is seeking a highly motivated, collaborative scientist to support mass spectrometry-based immunogenicity assessment. The successful candidate will contribute to the execution of MHC-Associated Peptide Proteomics (MAPPs) studies and related LC-MS workflows used to characterize antigen presentation and support biologics, conjugates and peptides programs. The ideal candidate will primarily perform laboratory-based activities and be responsible for executing cell-based and immunoaffinity workflows, preparing samples for LC-MS analysis, maintaining laboratory instrumentation, and generating high-quality experimental data. The candidate will work in a multidisciplinary environment alongside scientists in immunology, bioanalysis, and mass spectrometry and will have opportunities to present findings at departmental meetings and contribute to scientific publications and presentations.
Requirements
- Hands-on experience with fundamental laboratory techniques, including pipetting, sample preparation, buffer preparation, and laboratory documentation
- Understanding of immunoaffinity (IA) or antibody-based enrichment techniques
- Experience operating or supporting LC-MS workflows and bioanalytical instrumentation
- Experience maintaining mammalian cell cultures and performing routine cell-based laboratory procedures
- Familiarity with high-resolution mass spectrometry (e.g., Orbitrap) platforms and associated data acquisition software
- Ability to collect, document, and analyze experimental data
- Understanding of research principles and experimental methodology
- Demonstrated attention to detail, organization, and commitment to generating high-quality scientific data
Nice To Haves
- Knowledge of MAPPs (MHC-associated peptide proteomics) workflows and immunogenicity assessment strategies
- Familiarity with Thermo Scientific Orbitrap mass spectrometry platforms, including Eclipse Orbitrap systems
- Experience with proteomics sample preparation, peptide characterization, and mass spectrometry-based proteomics workflows
- Experience with automated liquid handling systems, robotics, or laboratory automation platforms
- Experience using proteomics data analysis software such as Proteome Discoverer, MaxQuant, Genedata Expressionist, Peaks, or related tools
- Experience working in a pharmaceutical, biotechnology, or research-driven environment
Responsibilities
- Execute MAPPs (MHC-associated peptide proteomics) experiments to support immunogenicity risk assessment of therapeutic candidates.
- Maintain and expand human cell cultures, including routine cell maintenance, cell counting, viability assessment, and preparation of samples for downstream analysis.
- Perform immunoaffinity enrichment workflows, including antibody-based capture, antigen processing, and sample preparation for LC-MS analysis.
- Operate, maintain, and troubleshoot LC-MS instrumentation, including Orbitrap-based high-resolution mass spectrometry platforms.
- Generate, document, and review high-quality experimental data following established laboratory procedures and data integrity standards.
- Support optimization of sample preparation workflows and laboratory automation initiatives to improve efficiency and reproducibility.
- Maintain laboratory equipment, consumables, and records while ensuring compliance with safety and quality requirements.
Benefits
- medical
- dental
- vision healthcare
- other insurance benefits (for employee and family)
- retirement benefits, including 401(k)
- paid holidays
- vacation
- compassionate and sick days
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
