Scientist, LNP Process Development
About The Position
Bristol Myers Squibb is seeking a motivated and detail-oriented Senior Associate Scientist to join our LNP Process Development team in Cambridge, MA. The LNP PD team works to develop, characterize, and implement robust preclinical and clinical manufacturing processes to support Bristol Myers Squibb's exciting pipeline of products. This role is specifically focused on LNP process development, with responsibilities spanning early process development through clinical manufacturing support. This is an excellent opportunity for an early-career scientist to grow within a dynamic, fast-paced environment. The successful candidate will support planning and execution of laboratory studies and contribute to protocols, technical reports, and regulatory documentation under the guidance of senior team members.
Requirements
- Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field
- BS with 6+ years’ experience in science related disciplines
- MS with 4-6 years’ experience in science related disciplines
- PhD with 0 - 2 years’ experience in science related disciplines
- Expertise in nanoprecipitation, filtration (TFF/UF-DF), and innovative separation unit operations
- Solid knowledge foundation of statistical design of experiments (DoE) and analysis of multivariate data
- Experience with performing process analytics and biophysical characterization techniques such as DLS, ribogreen, and HPLC
- Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing
- Demonstrated background of providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications
Nice To Haves
- Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
- Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus
Responsibilities
- Execute hands-on laboratory experiments focused on LNP process development and scale-up from bench to pilot scale
- Design and perform experiments for optimization and characterization of targeted lipid nanoparticles using structured approaches in both upstream and downstream unit operations (i.e. QbD principles, DoE)
- Contribute to the authoring and review of technical protocols, experimental reports, and batch records in support of early- to late-stage development activities
- Perform routine analytical testing to assess LNP characterization
- Analyze and interpret experimental results, present findings to senior scientists and project teams
- Collaborate with internal R&D, analytical development, and manufacturing to advance BMS's LNP pipeline
- Support interactions with manufacturing partners, including review of technical documents and participation in technology transfer activities as needed
- Maintain accurate and complete laboratory notebooks and documentation in compliance with internal quality standards
Benefits
- wellbeing support
- retirement and financial protection benefits
- insurance offerings (medical, dental, vision, life and disability)
- Flexible Time Off (FTO)
- 11 paid company holidays each year
- 160 hours of paid vacation annually for new hires
- 3 optional holidays
- paid sick leave
- up to two paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
- annual Global Shutdown between Christmas Day and New Year's Day
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
No Education Listed
