Scientist/Lab Manager Bioscience Immunology, Respiratory and Immunology

AstraZeneca • Cambridge, MA

1d • $92,252 - $138,378 • Hybrid

About The Position

This is a dual-impact role where you will lead the heartbeat of our laboratory while advancing innovative research with direct line of sight to patients. You will be based in Waltham, MA through October 2026 and then transition to our new, state-of-the-art research facilities in Cambridge, MA. Approximately 40–50% of your time will be dedicated to leading laboratory operations, and 50–60% to driving bench science that validates new targets and informs drug discovery strategy. This role thrives at the intersection of operational excellence and hands-on science, where well-run labs, robust assays, and clear data narratives speed decisions and move programs forward.

Requirements

• Master’s degree in Immunology or a related scientific discipline with a minimum of 3 years of relevant experience.
• Experience managing aspects of a biological research laboratory in an academic and/or biopharmaceutical industry setting.
• Highly organized and self-motivated with the ability to work independently and collaboratively to deliver high-quality research outcomes.
• Strong hands-on experience with biochemical, immunological and molecular biology techniques, including cell line culture, mRNA quantification (qPCR), protein expression analysis, ELISA, Western blotting, immunoprecipitation, MSD, Luminex, etc.
• Demonstrated expertise in primary human cell culture, including co-culture systems and tissue cell isolation/extraction, as well as strong experience in multiparametric flow cytometry, including staining of intracellular and extracellular proteins.
• Strong written and verbal communication skills with the ability to critically evaluate and interpret complex data sets.
• Demonstrated ability to run collaborative efforts and utilize external resources to find the most effective solutions to drug discovery problems.
• Strong commitment to accurate and timely documentation of protocols, experimental results and maintenance of a high-quality laboratory notebook.

Nice To Haves

• Expertise in drug discovery within immunology or a closely related area of biology.
• Deep scientific expertise in T-cell, B-cell and innate immune biology, and/or in the mechanisms underlying tissue pathology in immune-mediated diseases.
• Hands-on experience with advanced co-culture systems, multiparametric flow cytometry and cell imaging technologies to generate mechanistic insights into human immune-mediated disease.
• Experience establishing or scaling human tissue culture assays and co-culture models in support of discovery programs.
• Familiarity with best practices for human biological sample handling and storage aligned to quality standards.

Responsibilities

• Own daily lab readiness and compliance, ensuring space planning, equipment allocation and maintenance schedules keep science moving without interruption.
• Optimize footprint, instrument access and utilization to increase productivity and reduce cycle time across multiple projects.
• Drive research on immunological pathways in health and disease to support target validation and strengthen the therapeutic pipeline.
• Independently design, execute and troubleshoot molecular and cellular experiments; analyze complex datasets and translate findings into clear, decision-enabling recommendations.
• Develop and implement human tissue culture assays and advanced co-culture systems that generate mechanistic insights into immune-mediated disease.
• Partner with colleagues across our US and international research hubs to share data, align methods and accelerate portfolio progress.
• Clearly communicate results to multidisciplinary teams, shaping scientific hypotheses and next-step plans.
• Manage human biological sample handling and storage in accordance with quality standards to ensure data integrity and compliance.
• Build strategies for novel target identification and validation that expand options for therapeutic intervention and de-risk downstream development.
• Engage in professional development to deepen specialist knowledge, expand technical breadth and raise the bar for team capability.

Benefits

• Qualified retirement programs
• Paid time off (i.e., vacation, holiday, and leaves)
• Health coverage
• Dental coverage
• Vision coverage
• Eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles

What This Job Offers

• Job Type: Full-time
• Career Level: Senior