Scientist, In Vivo Biology

Flagship Pioneering, Inc.•Boston, MA

22d•$100,000 - $143,000

About The Position

FL106 is seeking a highly motivated Scientist for In Vivo & Translational biology to lead the design and execution of rigorous in vivo and ex vivo assays in support of novel drug delivery technologies. This role will be central to evaluating delivery performance, biodistribution, and biological activity across relevant model systems. The ideal candidate is an independent, goal-oriented scientist with strong experimental dexterity and judgment, excellent communication skills, and a bias toward execution. You will work in a highly dynamic, fast-paced, and collaborative entrepreneurial environment, contributing directly to scientific strategy and data-driven decision-making. This is a unique opportunity to help build an early-stage biotechnology company and shape the next frontier of drug delivery.

Requirements

PhD in Biology, Cell Biology, Immunology, or a related field
2+ years of experience in the biopharmaceutical or biotechnology industry preferred
Extensive hands-on experience with in vivo biology in small rodents (mice required; rats preferred)
Proficiency in high-throughput animal handling, injection techniques, and tissue harvesting and processing (IV, subcutaneous required other routes of administration – e.g. IM, IVT, IT, preferred)
Proven expertise in protein and/or nucleic acid (DNA/RNA) isolation from mammalian cells and tissues, cDNA synthesis, and qPCR
Experience with histological techniques, including tissue preparation, staining and data analysis
Strong organizational and planning skills, with attention to experimental rigor and reproducibility

Nice To Haves

Experience with non-invasive in vivo imaging technologies, including bioluminescence and fluorescence imaging, strongly preferred
Experience performing whole-body perfusion,single cell organ digestion, and cell sorting strongly preferred
Hands-on experience with flow cytometry, including sample preparation, panel design or execution, data acquisition, and downstream analysis, strongly preferred
Proven ability to develop, optimize, and troubleshoot biological assays

Responsibilities

Design, plan and execute mouse and rat studies, including experimental design, protocol development, dosing, tissue collection and processing, and data analysis to evaluate delivery technologies
Perform readout assays such as flow cytometry, immunofluorescence imaging, bioluminescence, qPCR, and histology
Manage and collaborate with CROs and external partners to ensure high-quality execution of outsourced studies
Work closely with interdisciplinary team members (e.g., chemistry, engineering, formulation) to develop integrated experimental plans
Contribute to the development and refinement of translational and preclinical scientific strategy
Clearly communicate experimental results and insights through concise presentations, written summaries, and thorough documentation in an electronic lab notebook (ELN)
Stay current with relevant scientific literature and emerging technologies, proactively sharing insights with the broader team