Scientist III - LC/MS (Bioanalytical)

BioAgilytix • Durham, NC

1d • Onsite

About The Position

At BioAgilytix, we are passionate about premier science and the impact it has on our world. Our team of highly experienced scientists and professionals deliver tailored services for supporting new medicine breakthroughs with best-in-class bioanalytical services. We are tirelessly committed to our customers by being solution-oriented and deadline-driven. . . and we are growing. Our culture is fast-paced, fun and never boring. Because we work across numerous clients and drug modalities, your career can develop rapidly. You’ll gain experience with a variety of challenges all while you enable life-changing, life-saving therapeutics to the patients who need them.

In this hands-on, laboratory-based Scientist role, you will design, develop, and execute bioanalytical methods and experiments supporting the advancement of new therapies, with a particular focus on large-molecule LC/MS applications. You’ll spend much of your time at the bench performing method development, optimization, and GxP-compliant validation; generating and analyzing data; evaluating assay performance; and conducting targeted and untargeted analyses using liquid chromatography and mass spectrometry.
This role is a strong fit for someone who enjoys being in the lab, working through complex scientific problems, and seeing a method through from development to validation and execution. You’ll work across a variety of client programs and therapeutic areas, which means the science and day-to-day challenges can vary quite a bit. We’re looking for someone with strong LC/MS experience who is comfortable working in a regulated environment and understands the importance of producing accurate, high-quality data.

Requirements

• Experience with development, validation and execution of chromatographic and mass spectrometric assays (LC/MS), and/or ability to perform most tasks associated with custom research planning and bench work
• Must work effectively within team to meet objectives under time constraints
• Ability to take direction well and multi-task
• Detail oriented and highly organized
• Demonstrated expertise in chromatographic assay development
• Advanced capabilities in data analysis, data visualization statistical analysis
• LC/MS assay development and validation
• Microsoft word, Excel, Sciex OS/Analyst, MassLynx, Chromeleon, Watson LIMS, JMP, Graphpad Prism
• Ability to develop protein binding, CYP inhibition, CYP induction, or CYP phenotyping and/or ability to develop chromatographic assays using HPLC or LC/MS/MS.
• Experience working in a GxP environment preferred
• Excellent oral and written communication skills
• Bachelor’s degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than 12 years’ experience in a scientific laboratory environment; or
• Master’s degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than ten (10) years’ experience in a scientific laboratory environment; or
• PhD in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than eight (8) years’ experience in a scientific laboratory environment
• Demonstrated expertise in developing chromatographic and mass spectrometric assays including LC/MS and LC/MS/MS for bioanalytical studies by extracting analytes of interest from complex biological matrices using protein precipitation, liquid-liquid, solid phase, immunoprecipitation or other extraction technique
• Advanced capabilities in data analysis, data visualization statistical analysis

Nice To Haves

• This position may supervise Analyst I/II/III

Responsibilities

• Lead assay development, validation, and sample analysis of biologics, proteins, peptides, ADCs, and/or biomarkers using chromatographic and mass spectrometric (LC/MS) techniques in support of preclinical, clinical, and product release studies.
• Plan and direct experimental design for junior staff
• Drive bioanalytical projects to align with client timelines
• Frequent communication with clients to discuss technical details and provide project updates.
• Advise clients on LC/MS assay best practices
• Author documents (methods, SOPs, reports)
• Statistical analysis of bioanalytical data
• Review of documentation
• Peer review raw data
• Prepare reagents
• Troubleshoot assays
• Design assay runs independently
• Responsible for prompt identification and notification of deviations
• Write plans/reports for sample analysis
• Order and keep accurate inventories of supplies for laboratory needs and forecast future needs based on projected project needs
• Perform assays according to GLP guidance or SOPs
• Other duties as needed

Benefits

• Medical Insurance (HDHP with HSA; PPO)
• Dental Insurance
• Vision Insurance
• Flexible Spending Account (medical; dependent care)
• Short Term Disability
• Long Term Disability
• Life Insurance
• Paid Time Off (4 weeks per year)
• Parental Leave
• Paid Holidays (9 scheduled; 5 floating)
• 401k with Employer Match
• Employee Referral Program

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree