Scientist III, Discovery Chemistry (Peptide Synthesis)

Arrowhead Pharmaceuticals•San Diego, CA

14h•$120,000 - $130,000•Onsite

About The Position

Arrowhead Pharmaceuticals is seeking a highly motivated Scientist to join its discovery chemistry team at the San Diego site. The role focuses primarily on peptide synthesis and analysis and contributes to the development and optimization of siRNA-based therapeutics by applying expertise in peptide chemistry. The position is onsite five days a week in San Diego.

Requirements

PhD in chemistry or a related field with 0–2 years of experience, or a master's degree in chemistry or a related field with 5 or more years of experience.
Hands-on experience operating automated peptide synthesizers.
Demonstrated experience designing, synthesizing, and characterizing macrocyclic and/or bicyclic peptides, including incorporating noncanonical amino acids and backbone modifications.
Proficiency with a wide range of analytical techniques, especially HPLC and LCMS.
Strong scientific problem-solving skills and ability to independently design and troubleshoot experiments.
Excellent written and verbal communication skills, including the ability to present scientific data, interpretations, and recommendations clearly to cross-functional teams.
Current, valid authorization to work in the country where the role is located.

Nice To Haves

Experience with high-throughput screening technologies such as phage display, mRNA display, DEL, or OBOC.
Familiarity with biophysical assays for characterizing biomolecular interactions.
Experience applying SAR principles to peptides for hit-to-lead optimization.

Responsibilities

Independently design, execute, and troubleshoot solid-phase peptide synthesis (SPPS) workflows using automated and manual techniques.
Purify and analyze peptides using chromatography and mass spectrometry.
Analyze and integrate chemical, biological, and pharmacokinetic data to establish structure–activity relationships (SAR) and guide compound design.
Collaborate with cross-functional teams to advance delivery platform development.