Scientist II

Universities of Wisconsin•Madison, WI

1d•Onsite

About The Position

The Topkara Laboratory in the Department of Medicine, Division of Cardiovascular Medicine at University of Wisconsin - Madison School of Medicine and Public Health is seeking to recruit an outstanding Scientist II to study transcriptional regulatory mechanisms of heart failure and myocardial recovery. Leveraging our cardiac tissue repository from patients undergoing left ventricular assist device (LVAD) implantation and cardiac transplantation, we utilize state-of-art techniques including high-throughput sequencing, computational genomics, human iPSC-derived cardiomyocytes, and genetically engineered mouse models to discover and characterize new gene targets for heart failure. Current projects are focusing on understanding the role of non-coding RNAs, RNA binding proteins, and RNA splicing regulation in heart failure and myocardial recovery. The Scientist II will perform experiments to characterize genetically modified mice models and delineate the mechanism of RNA processing dysregulation during heart failure. This position requires work to be completed onsite, at a designated campus work location.

Requirements

Expertise in cellular and molecular biology techniques, cell culture and differentiation, and genetically engineered mouse models
Research publications and presentations
Experience in cardiovascular research and cardiac phenotyping
Ph.D. in Biological Sciences, Healthcare, or closely related field is required by the start date of the position.

Nice To Haves

Background in bioinformatic of high-throughput genetic data analysis including RNA sequencing and/or GWAS

Responsibilities

Serves as a unit subject matter expert and liaison to internal and external stakeholders providing advanced level information and representing the interests of a specialized research area
Attends and assists with the facilitation of scholarly events and presentations in support of continued professional development and the dissemination of research information
Collects and analyzes complex research data, conducts experiments and interviews, and documents results according to established policies and procedures under general supervision
Writes or assists in developing grant applications and proposals to secure research funding
Identifies research problems and develops complex research methodologies and procedures
Conducts literature reviews, prepares reports and materials, and disseminates information to appropriate entities
May supervise the day-to-day activities of a research unit as needed