Scientist II/Senior Scientist, Biology

Atavistik Bio•Cambridge, MA

1d•Onsite

About The Position

Atavistik Bio is a privately-held clinical stage biotechnology company accelerating the discovery and development of transformative precision allosteric therapeutics to address serious unmet patient needs. Our proprietary AMPS™ platform allows us to rapidly unlock functional cryptic pockets across a broad range of target classes to accelerate the development of groundbreaking medicines. We have rapidly established an emerging pipeline of allosteric therapeutics with the potential to achieve superior efficacy and tolerability profiles by leveraging the power of allostery. Atavistik Bio is led by an experienced team of drug hunters with a proven track record of developing marketed small molecule therapies and supported by top-tier investors, including The Column Group, Nextech Invest, Lux Capital, Regeneron Ventures, and RA Capital Management. We are seeking a strategic and dynamic Scientist II/Senior Scientist with deep expertise in probing GPCR signaling in cell and animal models, to join our R&D group and work with an enthusiastic team of highly skilled scientists in a fast-paced environment. Reporting to the SVP, Head of Biology, this individual will be responsible for leading screening campaigns for small molecule drug candidates. The ideal candidate will have extensive experience in developing cell-based assays to measure multiple GPCR-dependent read-outs, high-throughput screening, and the ability to work cross-functionally in a dynamic environment. This position is primarily lab-based, and will also involve CRO-management.

Requirements

PhD. in Biology or a related field.
2+ years of experience working with cell-based assays to screen and identify modulators of GPCRs, preferably with small molecules.
5+ years of laboratory experience working with immortalized and primary cell lines; strong foundation in standard molecular biology techniques including engineering cell lines, generating CRISPR-based knockout cell lines, western blotting and multi-well plate-based cellular assays.
Strong interpersonal skills and ability to build strong collaborative relationships in a cross-functional environment are a must.
Strong oral and written communication skills, with experience presenting complex scientific data to both internal and external stakeholders.

Responsibilities

Work closely with the broader drug discovery scientific team to progress compounds from screening to preclinical animal models.
Perform a wide range of cell-based assays to identify and characterize novel modulators of GPCRs and other therapeutic targets in on-site wet lab.
Work with CROs and academic partners on a wide-range of drug discovery efforts including cell-based screening and primary patient cell-based assays.
Partner with CROs and academic partners to design and execute in vivo PK/PD and efficacy models.
Clearly communicates the biology, screening data, and other information to team members to enable efficient interpretation and decision making.