Scientist II, Process Chemistry

Abzena • Bristol, PA

3d • Onsite

About The Position

With extensive experience in developing biologics and bioconjugates, we offer a seamless service delivered by fully integrated teams, from early discovery to commercial manufacturing. Forward-thinking and committed, we find the best solution and use the right technologies to design, develop and manufacture your products to ensure we get vital medicines to patients quickly and safely. We are dedicated to quality excellence. We are driven to get better treatments to market, efficiently and responsibly by reducing timelines and delivering the highest quality products and services. We are Abzena. More than a CDMO, we are a responsible and dedicated partner that takes care of your products from concept to patient. We are seeking a highly motivated Scientist II to join our Process Development team. The successful candidate will lead the development, optimization, and scale-up of synthetic processes for small molecules, linker-payloads, intermediates, and related compounds from early development through cGMP manufacturing. This role requires strong technical expertise, excellent problem-solving skills, and the ability to collaborate effectively with cross-functional teams.

Requirements

• Ph.D. in Organic Chemistry with 1+ years of industrial experience, or M.S. in Organic Chemistry with 4+ years of industrial experience
• Strong knowledge of synthetic organic chemistry and process development.
• Experience with reaction optimization, impurity control, and process scale-up.
• Experience with analytical techniques such as UPLC, HPLC, LC-MS, GC, and NMR.
• Excellent scientific writing, communication, and presentation skills.
• Demonstrated ability to manage multiple projects in a fast-paced environment.

Nice To Haves

• Experience in pharmaceutical, biotechnology, or CDMO environments.
• Experience supporting cGMP manufacturing campaigns and technology transfer.
• Experience with linker-payload synthesis, peptide coupling chemistry, or highly potent compounds is desirable.

Responsibilities

• Design, execute, and optimize synthetic routes for small molecules, intermediates, and complex drug-linker compounds.
• Develop scalable, robust, and cost-effective manufacturing processes suitable for pilot plant and cGMP production.
• Plan and perform laboratory experiments, analyze data, and interpret results to guide process improvements.
• Troubleshoot challenging synthetic and scale-up issues using sound scientific principles.
• Collaborate with Analytical Development, Manufacturing, MSAT, Quality, Supply Chain, and Project Management teams to ensure successful technology transfer and manufacturing campaigns.
• Prepare technical reports, batch records, process descriptions, risk assessments, and technology transfer documentation.
• Maintain accurate laboratory notebooks and ensure documentation complies with company and regulatory standards.
• Contribute to continuous improvement initiatives focused on safety, quality, efficiency, and sustainability.

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level