Scientist II or Senior Scientist, Protein Analytics

Alloy Therapeutics • Waltham, MA

9d • $130,000 - $160,000 • Onsite

About The Position

Alloy’s Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities. We are seeking a highly motivated Scientist or Senior Scientist to conduct biophysical screening and analytical characterization as part of our dynamic, fast-paced biotech team. In this role, you will design & execute high-throughput screening, stability, forced degradation, and pre-formulation experiments using various analytical techniques. You will work collaboratively in a matrixed environment to advance biologics discovery and support rapid, data-driven decision-making. This role will report to the Head of Protein Analytics and offers significant autonomy, with ownership of multiple stakeholders, projects, and tasks in a dynamic start-up environment, while maintaining the pace and standards of Alloy.

Requirements

• Ph.D. with at least 2 years of relevant industry experience, or M.S. with at least 6 years of relevant industry experience.
• Proven track record of expertise in various protein analytical and/or biophysical assessments.
• Hands-on experience with LC-MS, CE-SDS, CZE or cIEF, DLS, and various chromatographic techniques such as SEC, HIC, etc.
• Experience with high concentration stability, forced degradation, and / or impurity characterization studies, preferably within an industry setting.
• Experience in the maintenance and troubleshooting of analytical instrumentation.
• Demonstrated ability to troubleshoot and maintain analytical instrumentation.
• Excellent written and verbal communication skills, with the ability to clearly present complex scientific data.
• Ability to effectively multitask and deliver results within project-driven timelines.
• Strong sense of ownership, urgency, persistence, and scientific integrity.
• Excellent organization, clear communication and teamwork abilities in a multidisciplinary setting.
• Thrives working on a team and collaborating with others to achieve project goals.
• Enjoys a dynamic and exciting work environment.
• Detail oriented, with rigorous scientific thinking and a passion for drug discovery to improve patients’ lives.

Nice To Haves

• Preferred experience with protein-binding (BLI, SPRi), and/or cell-binding (Flow Cytometry).

Responsibilities

• Independently design and execute high-throughput screening, stability, forced degradation, and pre-formulation studies to characterize monoclonal and multispecific antibodies and other modalities at various stages of development.
• Develop, validate, and optimize advanced analytical methods and workflows for high-throughput screening, stability, forced degradation, and impurity characterization, establishing best practices across the team.
• Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and developability packages that inform key program decisions.
• Partner across multi-disciplinary teams and Alloy sites, and supervise and mentor junior scientists, reviewing their experimental design and data to ensure quality and consistency.
• Clearly present complex data, conclusions, and recommendations to internal stakeholders and cross-functional teams.
• Independently design and execute high-throughput screening, stability, forced degradation, and pre-formulation studies using LC-MS, CE-SDS, CZE/cIEF, DLS, SPRi, BLI, and chromatographic techniques (SEC, HIC, etc.).
• Lead later-stage characterization efforts, including high-concentration stability and impurity characterization studies, to support developability and formulation decisions.
• Develop and validate new analytical methods, and optimize existing workflows for improved throughput, sensitivity, and reproducibility.
• Supervise and mentor junior scientists: providing technical guidance, reviewing experimental designs and data, and supporting their professional development.
• Maintain analytical instrumentation and ensure best practices and troubleshooting protocols are followed across the team.
• Support protein binding assays using BLI (Octet) and SPRi (Carterra LSA), as needed.
• Present experimental data, interpretations, and recommendations during team and cross-functional meetings.
• Ensure timely and successful execution of project activities, proactively identifying and resolving technical challenges.
• Maintain detailed and accurate laboratory records and ensure laboratory organization and compliance with safety protocols.

Benefits

• Competitive base and equity compensation commensurate with level of experience and independence
• 401(k) company match
• Generous personal and family medical, dental and vision benefits with 100% of premiums and deductibles covered
• Company-paid disability (STD, LTD) and life insurance
• Paid parental leave
• Family planning support up to $45,000 (e.g., IVF/PGT, adoption, surrogacy, egg retrieval)
• Unlimited PTO (paid time off) and flexible schedules
• Annual stipend for continuing education with commitment to your career through individualized professional development plan
• Wellness and Extensive Employee Assistance Program (EAP) including resources for mental wellness

What This Job Offers

• Job Type: Full-time
• Career Level: Mid Level