Scientist II, Biologics Research
About The Position
At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK. For patients, for each other, and for the future of science, we’re in. Are you? About the Role: We’re looking for a Scientist, Biologics Research on the Biologics Research team to help us expand what’s possible for patients with serious diseases. Reporting to the Senior Director, Research, you’ll work within a multidisciplinary team of scientists focused on the design, engineering, formulation development, and preclinical characterization of ground-breaking biotherapeutics. Specifically, you will help lead engineering and optimization campaigns for a diverse array of biomolecular scaffolds including enzymes, catalysts, binding and targeting moieties, signaling molecules, and drug delivery platforms of biological origin.
Requirements
- PhD in molecular and cellular biology, bioengineering, biochemistry, immunology, microbiology or related fields
- Deep technical understanding of and hands-on experience with molecular and cellular biology, mammalian tissue culture, recombinant DNA technology, protein mutagenesis, and protein biochemistry
- Experience with recombinant protein expression and purification as well as routine protein characterization methods including but not limited to spectroscopy, SDS-PAGE, western blot, and ELISA
- Experience with enzyme analysis and characterization and/or protein-protein binding analysis and characterization
- Excellent communication (verbal and written) and problem-solving skills
- Highly organized with a strong attention to detail, clarity, accuracy, and conciseness
- Proven track record in methods development, including experimental design, execution, and evaluation
Nice To Haves
- Experience with high throughput functional screen development for protein libraries
- Experience with AAV viral vectors, gene editing, and in vivo (rodent) are also preferred but not required
Responsibilities
- Help drive biomolecular engineering, immunology, and pharmacology efforts within Insmed research projects, including strategy and methods development
- Construct recombinant systems encoding protein variants and combinatorial protein libraries
- Conceptualize, construct, validate, and implement high throughput screening platforms to enable candidate selection from large panels and/or combinatorial libraries of engineered protein variants
- Devise, optimize, and employ tailored protein expression and purification strategies for drug discovery programs
- Develop, validate, and deploy functional, immunological, and pharmacological, assays to characterize protein performance in vitro (both exogenous and cell-based assays) and in vivo
- Maintain accurate, detailed, and timely records of methods development, experimental data, and data analysis in an electronic notebook system
- Perform data review to ensure accuracy, completeness, and validity
- Participate in cross-disciplinary mentoring and training within the research team
- Present scientific results to the larger Insmed research group and external scientific community, as needed
Benefits
- Comprehensive medical, dental, and vision coverage and mental health support
- Annual wellbeing reimbursement
- Access to our Employee Assistance Program (EAP)
- Generous paid time off policies
- Fertility and family-forming benefits
- Caregiver support
- Flexible work schedules with purposeful in-person collaboration
- 401(k) plan with a competitive company match
- Annual equity awards
- Participation in our Employee Stock Purchase Plan (ESPP)
- Company-paid life and disability insurance
- Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
- Employee resource groups
- Service and recognition programs
- Meaningful opportunities to connect, volunteer, and give back
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
