Scientist II, Bioinformatics QC

Aspen Neuroscience•San Diego, CA

9h•$129,600 - $158,400•Onsite

About The Position

Aspen Neuroscience is seeking a Scientist II, Bioinformatics QC to join their team. This role involves taking ownership of a critical priority, bringing together multiple teams and ensuring product quality to deliver novel cell therapy to patients. The position requires applying bioinformatics and genomics expertise to support Quality Control operations for clinical-stage cell therapy manufacturing. The individual will be responsible for executing and analyzing multi-omics QC workflows, as well as improving bioinformatics processes, directly impacting patients with Parkinson's Disease. This is an on-site role in Torrey Pines, CA, requiring flexibility and availability for weekend and holiday work as needed. Relocation is not available.

Requirements

PhD in Bioinformatics, Genomics, Computational Biology, or related field (or equivalent combination of education and relevant experience)
Hands-on experience with NGS data analysis pipelines (RNA-seq, WGS, or similar)
Experience working in drug development or other regulated environments (GMP/GxP), including understanding of data integrity expectations
Strong understanding of human genetics and genomics, including variant analysis, gene expression, and structural variation in applied settings
Proficiency in scripting and data analysis tools (e.g., Python, R, Bash) to support reproducible workflows
Excellent attention to detail with demonstrated ability to produce accurate, high-quality, and traceable datasets
Familiarity with QC and QA workflows, documentation practices, and audit readiness requirements
Ability to interpret biological and genomics data in clinical or translational contexts to support QC decision-making
Strong written and verbal communication skills, with the ability to clearly document and explain analytical methods and results
Comfort working with ambiguity and applying scientific reasoning to analyze and troubleshoot real-world datasets
Exposure to qualification and validation of bioinformatics systems and pipelines in regulated environments
Ability to contribute to the design, improvement, and scaling of bioinformatics workflows and organizational systems

Responsibilities

Execute bioinformatics QC analyses across multi-omics assays (e.g., RNA-seq, WGS, structural variation, epigenetic profiling) to support product quality assessment and release
Analyze and interpret data against established acceptance criteria; escalate atypical results and support investigation activities
Prepare and maintain compliant documentation supporting QC review, deviation investigations, and audit readiness
Support root cause analysis and re-analysis workflows for QC deviations and process excursions
Maintain traceability of data, methods, and outputs in alignment with GMP and data integrity expectations
Collaborate with QC, QA, Manufacturing, and R&D teams to support sample processing timelines and data delivery
Contribute to process improvements, workflow optimization, and automation initiatives for bioinformatics QC
Assist in development and evaluation of new analytical methods to support characterization of product lots and intermediates
Support qualification and validation activities for bioinformatics pipelines and systems