Scientist II, Assay Development

Foresite Labs (Stealth Co)•San Diego, CA

23h•$110,000 - $120,000•Onsite

About The Position

We are seeking a Scientist II to support the development, optimization, and maturation of molecular methods for clinical next-generation sequencing (NGS) assays. This is a hands-on, bench-focused individual contributor role: executing the experiments that move nucleic acid extraction and library preparation methods from feasibility toward robust, automation-ready processes suitable for transfer to clinical lab operations. Working closely with senior scientists and process engineers, the Scientist II will run structured experiments, generate and analyze high-quality data, and contribute to the optimization of buffer formulations, reaction conditions, and process parameters that drive method performance and stability. The role is well suited to a scientist with strong molecular biology fundamentals and solid bench execution who is ready to grow toward independent method development in a rigorous, quality-oriented environment where methods are actively evolving.

Requirements

BS in Molecular Biology, Biochemistry, Chemistry, or a related field with 3+ years of relevant laboratory experience; or MS with 2+ years; or a PhD in a relevant field.
Solid molecular biology and biochemistry fundamentals, with hands-on experience in library preparation and workflows.
Demonstrated bench proficiency in core techniques, with accurate, reproducible execution and strong attention to detail.
Working familiarity with structured experimental design and data analysis.
Rigorous, well-organized record-keeping and the ability to generate clear technical data summaries.
Ability to execute independently on assigned experiments and manage parallel bench work in a fast-moving, early-stage environment.

Nice To Haves

Experience with low-input or other challenging workflows.
Hands-on experience with liquid handling platforms.
Exposure to a regulated or quality-driven environment and familiarity with design controls.
Programming or scripting experience (Python, R) for data analysis or experimental workflows.
Familiarity with QC metrics and data interpretation.
Comfort operating in a stealth-stage, resource-constrained environment where the development roadmap is actively evolving.

Responsibilities

Execute bench experiments that advance library preparation methods from feasibility toward production-ready performance.
Prepare and test buffer formulations and reaction conditions, and contribute to method optimization by generating and analyzing systematic, well-controlled data.
Execute systematic experiments, and perform data analysis to characterize method performance.
Run stability and robustness studies per established protocols, and summarize results clearly.
Support the transfer of bench methods including hands-on protocol execution, method-comparison runs, and troubleshooting.
Contribute to reagent QC by executing QC assays.
Support tech transfer and analytical validation activities through bench execution, troubleshooting, and documentation.
Maintain rigorous, well-organized experimental records (electronic lab notebook), generate clear data summaries and technical reports, and contribute to process and design documentation.
Collaborate with assay development, process engineering, automation, quality, and clinical operations to advance methods from feasibility through production.