Scientist I – Vector Development
About The Position
We are seeking a highly motivated Scientist I to support viral and non-viral vector development and genetic construct workflows in a fast-paced, collaborative, and execution-focused translational research environment. This role works closely with senior scientists engaged in lentiviral vector design, mRNA delivery systems, and transposon-based construct engineering. The ideal candidate has strong hands-on molecular biology skills and thrives in a detail-oriented laboratory environment focused on high-quality execution and reproducible experimental work. This position provides direct exposure to advanced gene delivery systems and offers significant opportunities for technical growth in translational genomics and gene therapy.
Requirements
- Bachelor’s degree in Biology, Molecular Biology, Biochemistry, Biotechnology, or a related field
- 1–3 years of hands-on laboratory experience in molecular biology and primary cell cultures (academic or industry setting)
- Proficiency in mammalian tissue culture techniques (passaging, counting, maintenance, freezing/thawing cells)
- Experience with bacterial culture and plasmid propagation
- Experience performing plasmid DNA purification workflows
- Familiarity with standard molecular biology techniques (pipetting, PCR, gel electrophoresis, restriction digests)
- Experience or familiarity with lentiviral vector production
- Understanding of sterile technique and biosafety best practices
- Familiarity with basic viral handling or BSL-2 laboratory environments
- Ability to follow detailed experimental protocols with high reproducibility
- Strong attention to detail and experimental consistency
- Ability to execute complex protocols accurately and reliably
- Strong organizational and documentation skills
- Collaborative mindset and willingness to support team-based research goals
- Eagerness to learn advanced molecular and gene delivery techniques
Nice To Haves
- Knowledge or experience with viral vector production downstream engineering (filtration, chromatography), especially as used with lentiviral systems
- Experience with transfection methods (e.g., PEI, lipid-based reagents, electroporation)
- Experience with DNA construct screening and validation workflows
- Exposure to cell-based functional assays or flow cytometry
Responsibilities
- Perform routine and advanced mammalian cell culture, including maintenance of adherent and suspension cell lines
- Assist in preparation and handling of reagents for transfection and transduction experiments
- Execute plasmid DNA preparation (ex. Maxiprep)
- Support quality control of plasmid constructs through restriction digest analysis, PCR, and basic sequencing preparation
- Conduct lentiviral production workflows, including transient transfection of packaging systems, viral harvest and downstream processing (concentration, purification)
- Assist in viral titering, concentration, and basic functional validation assays
- Support cloning workflows including bacterial transformation, colony screening, and plasmid expansion
- Perform sterile technique-based molecular and cell biology experiments with high accuracy and reproducibility
- Maintain detailed and accurate laboratory records, including experimental notes
- Collaborate closely with senior scientists to support iterative construct design and testing cycles
- Maintain laboratory organization, reagent stocks, and compliance with biosafety protocols (BSL-2 practices where applicable)
Benefits
- Salary range for this role when Hired for NYC Offices
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
