Scientist I / Scientist II, Cell-based High Throughput Screening

Neomorph•San Diego, CA

6d•Onsite

About The Position

We are seeking a Scientist to join our Lead Discovery team with a focus on cell-based high-throughput screening (HTS). This position may be filled at the Scientist I or Scientist II level based on the selected candidate’s education, experience, technical depth, demonstrated accomplishments, and ability to operate independently. The successful candidate will contribute directly to small-molecule drug discovery programs by developing, executing, and analyzing robust, miniaturized cell-based assays in a fast-paced biotechnology environment.

Requirements

Degree in Biology, Pharmacology, Biochemistry, Cell Biology, or a related scientific discipline, or an equivalent combination of education and relevant industry experience.
Hands-on experience with mammalian cell culture, including maintenance, transfection or transduction, and banking of multiple cell lines.
Experience developing or running quantitative cell-based assays using luminescence, fluorescence, time-resolved fluorescence, flow cytometry, high-content imaging, or related readouts.
Understanding of assay-performance and screening-quality metrics such as Z', signal-to-background, coefficient of variation, and concentration-response analysis.
Experience with laboratory automation, liquid handlers, plate readers, dispensers, or automated HTS workflows appropriate to career level.
Strong organizational skills, attention to detail, scientific judgment, and ability to manage multiple workflows and timelines.
Collaborative approach with strong verbal, written, and data-presentation skills.

Nice To Haves

Experience transferring, validating, and implementing assays on automated HTS platforms.
Experience with 384- and/or 1536-well assay formats and low-volume liquid handling.
Familiarity with high-content imaging, multiplexed readouts, or flow cytometry-based screening.
Experience generating stable cell lines or using inducible expression systems.
Background in molecular biology techniques such as cloning, CRISPR editing, or viral-vector production.

Responsibilities

Design, develop, optimize, and execute robust, reproducible cell-based assays to support high-throughput screening, hit confirmation, and hit-to-lead campaigns.
Culture, maintain, characterize, and bank mammalian cell lines used in screening and assay-development workflows.
Apply assay miniaturization, automation, and statistical quality-control principles to generate reliable screening data in 96-, 384-, and 1536-well formats.
Collaborate closely with biology, chemistry, automation, compound management, and data teams to plan and execute screening campaigns.
Troubleshoot assay performance, cellular readouts, liquid-handling methods, and sources of screening variability.
Analyze, interpret, and clearly communicate experimental and screening results in internal meetings, written reports, and electronic systems.
Maintain complete and timely documentation in electronic laboratory notebooks and other applicable data-management systems.
Contribute to the development, standardization, and continuous improvement of screening workflows, assay-quality practices, and automation processes.
Support assay transfer, validation, and implementation on automated HTS platforms.
Perform other duties as assigned.

Benefits

Industry competitive compensation
Annual target bonus
Stock options
401K plan
Career advancement opportunities
Monthly town halls to share business and scientific updates
Comprehensive medical, dental, and vision plans for employees and their dependents
Health and Dependent Care FSA and HSA Plan with monthly Neomorph contribution
Employee Assistance Program
10 holidays + Winter Shutdown + 3 weeks of vacation time with additional accruals after 2nd year of employment, separate sick leave.
Supplemental pay for Pregnancy Disability Leave
Paid Parental Leave for employees with a newborn child or a child placed with them for adoption or foster care
Flexible work schedule
Access to onsite gym
Onsite space to store your bicycle (or surfboard)
Volunteer days off each year to spend time contributing to causes you care about