Scientist I, Proteomics

Vividion Therapeutics•San Diego, CA

7d•Onsite

About The Position

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. We are seeking a scientist who is passionate about deploying chemical proteomics to interrogate biology and identify novel opportunities for small molecule drug discovery. The successful candidate will have hands-on experience in mass-spectrometry-based proteomics and chemical biology workflows to characterize the interaction of small molecule ligands with their protein targets. This position will be responsible for supporting efforts to enable ligand discovery against high-impact targets using a combination of proteomic, cellular and biochemical methods.

Requirements

Ph.D. (or equivalent experience) in mass-spectrometry based proteomics or chemical biology
Experience operating and maintaining orbitrap mass spectrometers and associated nano-LC systems
Demonstrated experience in acquiring, analyzing and interpreting proteomics datasets and familiarity with common MS software suites
Experience preparing samples for MS analysis utilizing workflows that include peptide enrichment, protein enrichment or PTM enrichment
Proficiency in mammalian cell culture, including cell line maintenance, transient transfections, stable cell line generation
Understanding of cell-based assays for characterization of the functional effects of tool compounds on biological pathways, protein-protein interactions, and cellular proliferation
Excellent communication and presentation skills within a setting of cross-functional program teams
Ability to prioritize tasks and manage time effectively in a dynamic, fast-paced research environment
Attention to detail and good organization and documentation habits
Self-motivated problem solver with a strong sense of independently developing experimental strategies to address key needs