Scientist I, Protein Science

Voyager Therapeutics•Lexington, MA

1d•$113,000 - $149,000

About The Position

About Voyager Therapeutics Voyager Therapeutics, Inc. (Nasdaq: VYGR) is a biotechnology company dedicated to leveraging the power of human genetics to modify the course of – and ultimately cure – neurological diseases. Our pipeline includes programs for Alzheimer’s disease, Friedreich’s ataxia, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and multiple other diseases of the central nervous system. Many of our programs are derived from our TRACER™ AAV capsid discovery platform, which we have used to generate novel capsids and identify associated receptors to potentially enable high brain penetration with genetic medicines following intravenous dosing. Some of our programs are wholly owned, and some are advancing with partners including Alexion, AstraZeneca Rare Disease; Novartis Pharma AG; and Neurocrine Biosciences, Inc. For more information, visit http://www.voyagertherapeutics.com . Voyager Therapeutics ® is a registered trademark, and TRACER™ is a trademark, of Voyager Therapeutics, Inc. Job Summary: Voyager Therapeutics is seeking a dedicated Scientist I, Protein Science, to join our growing Non-Viral Therapeutics Team. This role will be responsible for the purification, characterization, and delivery of high-quality proteins, including bispecific antibodies, antibody-oligonucleotide conjugates, and fusion proteins, to support the discovery and development of novel biotherapeutics. The ideal candidate should be fluent with protein purification methods including affinity, ion-exchange, and size exclusion-based chromatography, using computer interfaced systems. The candidate should be familiar with analytical methods for characterizing complex biotherapeutic molecules including SDS-PAGE, SEC-HPLC, light scattering, and thermal stability analysis. This role will require coordination and collaboration within the Protein Science and Bioconjugation group to generate both protein tool reagents and biotherapeutic candidates, and with Antibody Discovery and Engineering, and Biology teams to develop, optimize, and advance brain-penetrant biologics.

Requirements

PhD, MS, or BS in biochemistry, protein or cell engineering or related field, with 0-2 years or 7-8+ years respectively, of education and relevant industry experience
Extensive hands-on experience with protein purification and relevant chromatographic techniques
Direct hands-on experience with analytical characterization techniques (e.g. SDS-PAGE, SEC-HPLC, thermal stability, light scatter, differential scanning fluorimetry)
Self-motivated with an ability to multi-task multiple purifications, and scale purification to the requested amount of purified protein
Outstanding analytical, research and organizational skills
Excellent oral and written communication skills

Nice To Haves

Familiarity with AKTA Pure and AKTA Avant chromatographic systems is desired
Experience with bispecific antibody purification is preferable

Responsibilities

Utilize relevant chromatographic separation techniques (affinity, ion-exchange, size exclusion, HIC, multi-modal) to isolate desired homogenous protein
Execute workflows enabling high-throughput small scale protein purification for screening through gram scale production to support primate studies
Apply biophysical methods to assess size, monodispersity, thermal stability, and aggregation
Consistently deliver internally qualified high-quality protein for binding and functional assays, animal studies, and structure determination
Perform site-specific protein labeling and modification using enzymatic cleavage strategies (e.g., via proteases) and chemical conjugation approaches (e.g., NHS-reactive fluorophores and biotin)
Multiplex purifications to drive efficiency and shorter delivery times
Coordinate purification and characterization with requested timing of qualified protein delivery

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