Scientist I, Protein Science

Voyager Therapeutics • Lexington, MA

11h

About The Position

Voyager Therapeutics is seeking a dedicated Scientist I, Protein Science, to join our growing Non-Viral Therapeutics Team. This role will be responsible for the purification, characterization, and delivery of high-quality proteins, including bispecific antibodies, antibody-oligonucleotide conjugates, and fusion proteins, to support the discovery and development of novel biotherapeutics. The ideal candidate should be fluent with protein purification methods including affinity, ion-exchange, and size exclusion-based chromatography, using computer interfaced systems. The candidate should be familiar with analytical methods for characterizing complex biotherapeutic molecules including SDS-PAGE, SEC-HPLC, light scattering, and thermal stability analysis. This role will require coordination and collaboration within the Protein Science and Bioconjugation group to generate both protein tool reagents and biotherapeutic candidates, and with Antibody Discovery and Engineering, and Biology teams to develop, optimize, and advance brain-penetrant biologics.

Requirements

• PhD, MS, or BS in biochemistry, protein or cell engineering or related field, with 0-2 years or 7-8+ years respectively, of education and relevant industry experience
• Extensive hands-on experience with protein purification and relevant chromatographic techniques
• Direct hands-on experience with analytical characterization techniques (e.g. SDS-PAGE, SEC-HPLC, thermal stability, light scatter, differential scanning fluorimetry)
• Self-motivated with an ability to multi-task multiple purifications, and scale purification to the requested amount of purified protein
• Outstanding analytical, research and organizational skills
• Excellent oral and written communication skills

Nice To Haves

• Familiarity with AKTA Pure and AKTA Avant chromatographic systems is desired
• Experience with bispecific antibody purification is preferable

Responsibilities

• Utilize relevant chromatographic separation techniques (affinity, ion-exchange, size exclusion, HIC, multi-modal) to isolate desired homogenous protein
• Execute workflows enabling high-throughput small scale protein purification for screening through gram scale production to support primate studies
• Apply biophysical methods to assess size, monodispersity, thermal stability, and aggregation
• Consistently deliver internally qualified high-quality protein for binding and functional assays, animal studies, and structure determination
• Perform site-specific protein labeling and modification using enzymatic cleavage strategies (e.g., via proteases) and chemical conjugation approaches (e.g., NHS-reactive fluorophores and biotin)
• Multiplex purifications to drive efficiency and shorter delivery times
• Coordinate purification and characterization with requested timing of qualified protein delivery

What This Job Offers

• Job Type: Full-time
• Career Level: Entry Level
• Education Level: Ph.D. or professional degree